1. Tsao CW, Aday AW, Almarzooq ZI, et al. Heart disease and stroke statistics—2023 update: a report from the American Heart Association. Circulation. 2023;147:e93-e621

2. National Institute of Neurological Disorders and Stroke. Stroke. Available at https://www.ninds.nih.gov/health-information/disorders/stroke. Last accessed March 9, 2023.

3. American Heart Association/American Stroke Association. 2023 Heart Disease and Stroke Statistics Update Fact Sheet At-A-Glance. Available at https://professional.heart.org/-/media/PHD-Files-2/Science-News/2/2023-Heart-and-Stroke-Stat-Update/2023-Statistics-At-A-Glance-final_1_17_23.pdf. Last accessed March 7, 2023.

4. Elkins J, Johnston SC. Thirty-year projections for deaths from ischemic stroke in the United States. Stroke. 2003;34(9):2109-2112.

5. Ruland S, Richardson D, Hung E, et al. Predictors of recurrent stroke in African Americans. Neurology. 2006;67(4):567-571.

6. Brown DL, Boden-Albala B, Langa KM, et al. Projected costs of ischemic stroke in the United States. Neurology. 2006;67(8):1390-1395.

7. Kurth T, Moore SC, Gaziano JM, et al. Healthy lifestyle and the risk of stroke in women. Arch Intern Med. 2006;166(13):1403-1409.

8. Ovbiagele B, Levine SR. Addressing racial and ethnic disparities in stroke: the time is now. Neurology. 2006;67(8):1328-1329.

9. Meschia JF, Bushnell C, Boden-Albala B, et al. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(12):3754-3832.

10. Kleindorfer DO, Towfighi A, Chaturvedi S, et al. 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.Stroke. 2021;52:e354-e467.

11. Gladstone DJ. Toward an emergency response to transient ischemic attacks. Postgrad Med J. 2005;117(1):9-14.

12. Nguyen-Huynh MN, Fayad P, Gorelick PB, Johnston SC. Knowledge and management of transient ischemic attacks among U.S. primary care physicians. Neurology. 2003;61(10):1455-1456.

13. Holloway R, Benesch C, Rush SR. Stroke prevention: narrowing the evidence-practice gap. Neurology. 2000;54:1899-1906.

14. Castaldo J, Nester J, Wasser T, et al. Physician attitudes regarding cardiovascular risk reduction: the gaps between clinical importance, knowledge, and effectiveness. Dis Manag. 2005;8(2):93-105.

15. Christian AH, Mills T, Simpson SL, Mosca L. Quality of cardiovascular disease preventive care and physician/practice characteristics.J Gen Intern Med. 2006;21(3):231-237.

16. Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2019;50(12):e344-e418.

17. Duncan PW, Zorowitz R, Bates B, et al. Management of adult stroke rehabilitation care: a clinical practice guideline. Stroke. 2005;36(9):e100-e143.

18. Powers WJ, Derdeyn CP, Biller J, et al. 2015 American Heart Association/American Stroke Association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015;46(10):3020-3035.

19. Alberts MJ, Latchaw RE, Jagoda A, et al. Special report: revised and updated recommendations for the establishment of primary stroke centers: a summary statement from the Brain Attack Coalition. Stroke. 2011;42:2651-2665.

20. Adeoye O, Nystrom KV, Yavagal DR, et al. ASA policy statement: recommendations for the establishment of stroke systems of care: a 2019 update. Stroke. 2019;50:e187-e210.

21. Winstein CJ, Stein J, Arena R, et al. AHA/ASA guidelines for adult stroke rehabilitation and recovery. A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016;47:000-000.

22. World Health Organization. International Statistical Classification of Diseases and Related Health Problems, 11th Revision. Available at https://icd.who.int/browse11/l-m/en. Last accessed March 9, 2023.

23. Feigin VL, Lawes CM, Bennett DA, Anderson CS. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol. 2003;2(1):43-53.

24. National Heart, Lung, and Blood Institute. Morbidity and Mortality: 2012 Chart Book on Cardiovascular, Lung, and Blood Diseases. Available at https://www.nhlbi.nih.gov/files/docs/research/2012_ChartBook_508.pdf. Last accessed March 9, 2023.

25. Centers for Disease Control and Prevention. Stroke Resources for Health Professionals. Available at: https://www.cdc.gov/stroke/educational_materials.htm. Last accessed March 7, 2023.

26. Manno EM, Atkinson JL, Fulgham JR, Wijdicks EF. Emerging medical and surgical management strategies in the evaluation and treatment of intracerebral hemorrhage. Mayo Clin Proc. 2005;80(3):420-433.

27. Shah QA, Ezzeddine MA, Qureshi AI. Acute hypertension in intracerebral hemorrhage: pathophysiology and treatment. J Neurol Sci. 2007;261(1-2):74-79.

28. Hemphill JC 3rd, Greenberg SM, Anderson C, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015;46(7):2032-2060.

29. Counsell C, Boonyakarnkul S, Dennis M, et al. Primary intracerebral hemorrhage in the Oxfordshire Community Stroke Project: Prognosis. Cerebrovasc Dis. 1995;5:26-34.

30. Flaherty ML, Haverbusch M, Sekar PK, et al. Long-term mortality after intracerebral hemorrhage. Neurology. 2006;66(8):1182-1186.

31. Poon MT, Fonville AF, Al-Shahi Salman R. Long-term prognosis after intracerebral hemorrhage: systematic review and meta-analysis.J Neurol Neurosurg Psychiatry. 2014;85(6):660-667.

32. Sutherland GR, Auer RN. Primary intracerebral hemorrhage. J Clin Neuroscience. 2006;13:511-517.

33. Qureshi AI, Tuhrim S, Broderick JP, Batjer H, Hondo H, Hanley DF. Spontaneous intracerebral hemorrhage. N Engl J Med. 2001;344:1450-1460.

34. Ritter MA, Droste DW, Hegedüs, et al. Role of cerebral amyloid angiopathy in intracerebral hemorrhage in hypertensive patients. Neurology. 2005;64(7):1233-1237.

35. Kernan WN, Viscoli CM, Brass LM, et al. Phenylpropanolamine and the risk of hemorrhagic stroke. N Engl J Med. 2000;343:1826-1832.

36. Suarez JI, Tarr RW, Selman WR. Aneurysmal subarachnoid hemorrhage. N Engl J Med. 2006;354(4):387-396.

37. van Gijn J, Rinkel GJ. Subarachnoid haemorrhage: diagnosis, causes and management. Brain. 2001;124(Pt 2):249-278.

38. Niewwkamp DJ, de Wilde A, Wermer MJ, Algra A, Rinkel GJ. Long-term outcome after aneurysmal subarachnoid hemorrhage—risks of vascular events, death from cancer and all-cause death. J Neurol. 2014;261(2):309-315.

39. Mayer SA, Kreiter KT, Copeland D, et al. Global and domain-specific cognitive impairment and outcome after subarachnoid hemorrhage. Neurology. 2002;59(11):1750-1758.

40. MedlinePlus. Cerebral Arteriovenous Malformation. Available at https://medlineplus.gov/ency/article/000779.htm. Last accessed March 9, 2023.

41. Flaherty ML, Haverbusch M, Kissela B, et al. Perimesencephalic subarachnoid hemorrhage: incidence, risk factors, and outcome.J Stroke Cerebrovasc Dis. 2005;14(6):267-271.

42. Konczalla J, Kashefiolasl S, Brawanski N, Senft C, Seifert V, Platz J. Increasing numbers of nonaneurysmal subarachnoid hemorrhage in the last 15 years: antithrombotic medication as reason and prognostic factor? J Neurosurg. 2016;124(6):1731-1731.

43. Giles MF, Rothwell PM. Risk of stroke early after transient ischemic attack: a systematic review and meta-analysis. Lancet Neurol. 2007;6(12):1063-1072.

44. Albers GW, Caplan LR, Easton JD, et al. Transient ischemic attack-proposal for a new definition. N Engl J Med. 2002;347(21):1713-1716.

45. Dyken ML, Conneally, M. The Study Group on TIA Criteria and Detection. XI. Transient focal cerebral ischemia: epidemiological and clinical aspects. Stroke. 1974;5:277-284.

46. Ovbiagele B, Kidwell CS, Saver JL. Epidemiological impact in the United States of a tissue-based definition of transient ischemic attack. Stroke. 2003;34(4):919-924.

47. Easton JD, Saver JL, Albers GW, et al. Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. Stroke. 2009;40(6):2276-2293.

48. Rothwell PM, Giles MF, Chandratheva A, et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet. 2007;370(9596):1432-1442.

49. Fisher CM. Transient ischemic attacks. N Engl J Med. 2002;347(21):1642-1643.

50. Johnston SC, Gress DR, Browner WS, Sidney S. Short-term prognosis after emergency department diagnosis of TIA. JAMA. 2000;284(22):2901-2906.

51. Levy DE. How transient are transient ischemic attacks? Neurology. 1988;38(5):647-677.

52. Henry GL, Johnston SC, Pinkowish MD. Acute neurologic symptoms—TIA, migraine, or something else? Patient Care. 2004;38(3):50-56.

53. Nanda A. Transient Ischemic Attack. Available at https://emedicine.medscape.com/article/1910519-overview. Last accessed March 9, 2023.

54. Bos MJ, van Goor ML, Koudstaal PJ, Dippel DW. Plasma homocysteine is a risk factor for recurrent vascular events in young patients with an ischaemic stroke or TIA. J Neurol. 2005;252(3):332-337.

55. Muir KW, Buchan A, von Kummer R, Rother J, Baron JC. Imaging of acute stroke. Lancet Neurol. 2006;5(9):755-768.

56. Saver JL. Time is brain-quantified. Stroke. 2006;37:263-266.

57. Platz T. Evidenced-based guidelines and clinical pathways in stroke rehabilitation: an international perspective. Front Neurol. 2019;10:200.

58. Hewko C. Acute ischemic stroke-swift assessment and quick action produce optimal outcomes. JAAPA. 2004;17(7):19-25.

59. Savitz SI, Caplan LR. Vertebrobasilar disease. N Engl J Med. 2005;352(25):2618-2626.

60. Blumenfeld H. Neuroanatomy Through Clinical Cases. 2nd ed. Boston, MA: Sinauer Associates, Inc.; 2013.

61. Jauch EC. Ischemic Stroke. Available at https://emedicine.medscape.com/article/1916852-overview. Last accessed March 7, 2023.

62. Adams HP Jr, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST: Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24(1):35-41.

63. Petty GW, Brown RD Jr, Whisnant JP, Sicks JD, O'Fallon WM, Wiebers DO. Ischemic stroke subtypes: a population-based study of incidence and risk factors. Stroke. 1999;30(12):2513-2516.

64. Grau AJ, Weimar C, Buggle F, et al. Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bank. Stroke. 2001;32(11):2559-2566.

65. Frishman WH, Ismail AA. Role of infection in atherosclerosis and coronary artery disease: a new therapeutic target? Cardiol Rev. 2002;10(4):199-210.

66. Donnan G, Norrving B, Bamford J, Bogousslavsky J. Classification of subcortical infarcts. In: Donnan G, Norrving B, Bamford J, Bogousslavsky J (eds). Subcortical Stroke. 2nd ed. Oxford: Oxford Medical Publications; 2002: 27-34.

67. Vermeer SE, Longstreth WT Jr, Koudstaal PJ. Silent brain infarcts: a systematic review. Lancet Neurol. 2007;6(7):611-619.

68. Bokura H, Kobayashi S, Yamaguchi S, et al. Silent brain infarction and subcortical white matter lesions increase the risk of stroke and mortality: a prospective cohort study. J Stroke Cerebrovasc Dis. 2006;15(2):57-63.

69. Tuttolomondo A, Pinto A, Salemi G, et al. Diabetic and non-diabetic subjects with ischemic stroke: differences, subtype distribution and outcome. Nutr Metab Cardiovasc Dis. 2008;18(2):152-157.

70. Murtagh B, Smalling RW. Cardioembolic stroke. Curr Atherosclr Rep. 2006;8:310-316.

71. Ferro JM. Cardioembolic stroke: an update. Lancet Neurol. 2003;2:177-188.

72. Di Tullio MR, Homma S. Mechanisms of cardioembolic stroke. Curr Cardiol Rep. 2002;4:141-148.

73. MacDougall NJJ, Amarasinghe S, Muir KW. Secondary prevention of stroke. Expert Rev Neurother. 2009;7:1103-1115.

74. Khoo CW, Lip GYH. Clinical outcomes of acute stroke patients with atrial fibrillation. Expert Rev Neurother. 2009;7:371-374.

75. Olsen TS. Regional cerebral blood flow after occlusion of the middle cerebral artery. Acta Neurol Scand. 1986;73(4):321-337.

76. Kannel WB, Benjamin EJ. Status of the epidemiology of atrial fibrillation. Med Clin North Am. 2008;92(1):17-40, ix.

77. Arboix A, Alió J. Cardioembolic stroke: clinical features, specific cardiac disorders and prognosis. Curr Cardiol Rev. 2010;6(3):150-161.

78. Gardner C, Lee D, Lee K. Embolic stroke: classification, risk factors, and clinical pearls. Appl Neurol. 2006;2(7):27-33.

79. Komrad MS, Coffey CE, Coffey KS, et al. Myocardial infarction and stroke. Neurology. 1984;34(11):1403-1409.

80. Moncayo J, Devuyst G, Van Melle G, Bogousslavsky J. Coexisting causes of ischemic stroke. Arch Neurol. 2000;57(8):1139-1144.

81. Li L, Yin GS, Geraghty OC, et al. Incidence, outcome, risk factors, and long-term prognosis of cryptogenic transient ischaemic attack and ischaemic stroke: a population-based study. Lancet Neurol. 2015;14(9):903-913.

82. Fisher CM. Lacunes: small, deep cerebral infarcts, 1965. Neurology. 1998;50(4):841-852.

83. Papamitsakis NIH. Lacunar Syndrome: Lacunar Syndromes. Available at https://emedicine.medscape.com/article/1163029-overview#a5. Last accessed March 9, 2023.

84. Xu J, Murphy SL, Kochanek KD, Arias E. Deaths: final data for 2019. Natl Vital Stat Rep. 2021;70 (8):1-87.

85. National Institute of Neurological Disorders and Stroke. Post-Stroke Rehabilitation. Available at https://www.stroke.nih.gov/materials/rehabilitation.htm. Last accessed March 9, 2023.

86. National Institute of Neurological Disorders and Stroke. Stroke: Challenges, Progress, and Promise. Available at https://www.stroke.nih.gov/documents/NINDS_StrokeChallenge_Brochure_508C.pdf. Last accessed March 9, 2023.

87. Kelly-Hayes M, Beiser A, Kase CS, Scaramucci A, D'Agostino RB, Wolf PA. The influence of gender and age on disability following ischemic stroke: the Framingham study. J Stroke Cerebrovasc Dis. 2003;12(3):119-126.

88. Lackland DT, Roccella EJ, Deutsch AF, et al. Factors influencing the decline in stroke mortality: a statement from the American Heart Association/American Stroke Association. Stroke. 2014;45:315-353.

89. Sacco RL, Kasner SE, Broderick JP, et al. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(7):2064-2089.

90. Reeves MJ, Bushnell CD, Howard G, et al. Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes. Lancet Neurol. 2008;7:915-926.

91. Lewsey JD, Gillies M, Jhund PS, et al. Sex differences in incidence, mortality, and survival in individuals with stroke in Scotland, 1986 to 2005. Stroke. 2009;40:1038-1043.

92. Reeves MJ, Lisabeth LD. The confounding issue of sex and stroke. Neurology. 2010;74(12):947-948.

93. Seshadri S, Beiser A, Kelly-Hayes M, et al. The lifetime risk of stroke: estimates from the Framingham Study. Stroke. 2006;37:345-350.

94. Rothwell PM, Coull AJ, Silver LE, et al. Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study). Lancet. 2005;366:1773-1783.

95. Vega T, Zurriaga O, Ramos JM, et al. Stroke in Spain: epidemiologic incidence and patterns: a health sentinel network study. J Stroke Cerebrovasc Dis. 2009;18:11-16.

96. Sealy-Jefferson S, Wing JJ, Sanchez BN, et al. Age- and ethnic-specific sex differences in stroke risk. Gend Med. 2012;9:121-128.

97. Mozaffarian D, Benjamin EJ, Go AS, et al. Heart disease and stroke statistics–2016 update: a report from the American Heart Association. Circulation. 2016;133(4):e38-e360.

98. Smith MA, Lisabeth LD, Brown DL, Morgenstern LB. Gender comparisons of diagnostic evaluation for ischemic stroke patients. Neurology. 2005;65(6):855-858.

99. Mitka M. Studies explore stroke's gender gap. JAMA. 2006;295:1755-1756.

100. Gail SL, Donnan G, Dewey HM, et al. Sex differences in presentation, severity, and management of stroke in a population-based study. Neurology. 2010;74(12):975-981.

101. Towfighi A, Saver JL, Engelhardt R, Ovbiagele B. A midlife stroke surge among women in the United States. Neurology. 2007;69(20):1898-1904.

102. Labiche LA, Chan W, Saldin KR, Morgenstern LB. Sex and acute stroke presentation. Ann Emerg Med. 2002;40(5):453-460.

103. Towfighi A, Zheng L, Ovbiagele B. Sex-specific trends in midlife coronary heart disease risk and prevalence. Arch Intern Med. 2009;169(19):1762-1766.

104. White H, Boden-Albala B, Wang C, et al. Ischemic stroke subtype incidence among whites, blacks, and Hispanics: the Northern Manhattan Study. Circulation. 2005;111:1327-1331.

105. Joshipura KJ, Ascherio A, Manson JE, et al. Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA. 1999;282(13):1233-1239.

106. Mehdi Foroughi M, Akhavanzanjani M, Maghsoudi Z, Ghiasvand R, Khorvash F, Askari G. Stroke and nutrition: a review of studies. Int J Prev Med. 2013;4(Suppl 2):A165-S179.

107. Larsson SC, Wallin A, Wolk A. Dietary Approaches to Stop Hypertension diet and incidence of stroke: results from two prospective cohorts. Stroke. 2016;47(4):986-990.

108. Rodriguez BL, D'Agostino R, Abbott RD, et al. Risk of hospitalized stroke in men enrolled in the Honolulu Heart Program and the Framingham Study: a comparison of incidence and risk factor effects. Stroke. 2002;33(1):230-236.

109. Broderick JP, Viscoli CM, Brott T, et al. Major risk factors for aneurysmal subarachnoid hemorrhage in the young are modifiable. Stroke. 2003;34:1375-1381.

110. Bonita R, Duncan J, Truelsen T, Jackson RT, Beaglehole R. Passive smoking as well as active smoking increases the risk of acute stroke. Tob Control. 1999;8(2):156-160.

111. Centers for Disease Control and Prevention. Smoking and Heart Disease and Stroke. Available at https://www.cdc.gov/tobacco/campaign/tips/diseases/heart-disease-stroke.html. Last accessed March 9, 2023.

112. Centers for Disease Control and Prevention. Smoking-attributable mortality, years of potential life lost, and productivity losses— United States, 2000–2004. MMWR. 2008;57:1226-1228.

113. Prospective Studies Collaboration, Whitlock G, Lewington S, Sherliker P, et al. Body-mass index and cause-specific mortality in 900,000 adults: collaborative analyses of 57 prospective studies. Lancet. 2009;373:1083-1096.

114. Song YM, Sung J, Davey Smith G, Ebrahim S. Body mass index and ischemic and hemorrhagic stroke: a prospective study in Korean men. Stroke. 2004;35(4):831-836.

115. Strazzullo P, D'Elia L, Cairella G, Garbagnati F, Cappuccio FP, Scalfi L. Excess body weight and incidence of stroke: meta-analysis of prospective studies with 2 million participants. Stroke. 2010;41:e418-e426.

116. Hu G, Tuomilehto J, Silventoinen K, Sarti C, Männistö S, Jousilahti P. Body mass index, waist circumference, and waist-hip ratio on the risk of total and type-specific stroke. Arch Intern Med. 2007;167(13):1420-1427.

117. Toss F, Wiklund P, Franks PW, et al. Abdominal and gynoid adiposity and the risk of stroke. Int J Obes (Lond). 2011;35(11):1427-1432.

118. Hu G, Jousilahti P, Antikainen R, Katzmarzyk PT, Tuomilehto J. Joint effects of physical activity, body mass index, waist circumference, and waist-to-hip ratio on the risk of heart failure. Circulation. 2010;121(2):237-244.

119. Office of Disease Prevention and Health Promotion. Physical Activity Guidelines for Americans. Available at https://health.gov/sites/default/files/2019-09/Physical_Activity_Guidelines_2nd_edition.pdf. Last accessed March 9, 2023.

120. Rothwell PM, Coull AJ, Giles MF, et al. Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study). Lancet. 2004;363(9425):1925-1933.

121. Fields LE, Burt VL, Cutler JA, Hughes J, Roccella EJ, Sorlie P. The burden of adult hypertension in the United States 1999 to a rising tide. Hypertension. 2004;44:398-404.

122. Egan BM, Zhao Y, Axon RN. U.S. trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008. JAMA. 2010;303:2043-2050.

123. Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289(19):2560-2572.

124. U.S. Preventive Services Task Force. Screening for hypertension in adults: U.S. Preventive Services Task Force reaffirmation recommendation statement. JAMA. 2021;325(16):1650-1656.

125. Whelton PK, Carey RM, Aranow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APHA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018;71(6):e13-e115.

126. Bushnell C, McCullough LD, Awad IA, et al. Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(5):1545-1588.

127. Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2020: Estimates of Diabetes and Its Burden in the United States. Available at https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf. Last accessed March 9, 2023.

128. Collins R, Armitage J, Parish S, Sleigh P, Peto R, Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet. 2003;361(9374):2005-2016.

129. Lane DA, Lip GY. Anticoagulation intensity for elderly atrial fibrillation patients: should we use a conventional INR target (2.0 to 3.0) or a lower range? Thromb Haemost. 2010;103(2):254-256.

130. Hillis LD, Smith PK, Anderson JL, et al. 2011 ACCF/AHA guideline for coronary artery bypass graft surgery: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011;124(23):e652-e735.

131. Salaycik KJ, Kelly-Hayes M, Beiser A, et al. Depressive symptoms and risk of stroke: the Framingham Study. Stroke. 2007;38(1):16-21.

132. Lamberg L. Advances seen in mood disorders research. JAMA. 2006;296(10):1220-1222.

133. Müller-Nordhorn J, Nolte CH, Rossnagel K, et al. Knowledge about risk factors for stroke: a population-based survey with 28,090 participants. Stroke. 2006;37(4):946-950.

134. Schneider AT, Pancioli AM, Khoury JC, et al. Trends in community knowledge of the warning signs and risk factors for stroke. JAMA. 2003;289(3):343-346.

135. Rosamond WD, Gorton RA, Hinn AR, Hohenhaus SM, Morris DL. Rapid response to stroke symptoms: the Delay in Accessing Stroke Healthcare (DASH) study. Acad Emerg Med. 1998;5(1):45-51.

136. International Stroke Trial Collaborative Group. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19,435 patients with acute ischaemic stroke. Lancet. 1997;349(9065):1569-1581.

137. California Acute Stroke Pilot Registry (CASPR) Investigators. Prioritizing interventions to improve rates of thrombolysis for ischemic stroke. Neurology. 2005;64(4):654-659.

138. Wattigney WA, Croft JB, Mensah GA, et al. Establishing data elements for the Paul Coverdell National Acute Stroke Registry. Part 1: proceedings of an expert panel. Stroke. 2003;34(1):151-156.

139. Kothari RU, Pancioli A, Liu T, Brott T, Broderick J. Cincinnati Prehospital Stroke Scale: reproducibility and validity. Ann Emerg Med. 1999;33(4):373-378.

140. Kleindorfer DO, Miller R, Moomaw CJ, et al. Designing a message for public education regarding stroke: does FAST capture enough stroke? Stroke. 2007;38(10):2864-2868.

141. American Heart Association. Stroke Quiz English. Available at: https://www.stroke.org/en/about-stroke/stroke-risk-factors/stroke-quiz-english. Last accessed March 7, 2023.

142. Karliner L, Jacobs EA, Chen AH, Mutha S. Do professional interpreters improve clinical care for patients with limited English proficiency? A systematic review of the literature. Health Serv Res. 2007;42(2):727-754.

143. Ngo-Metzger Q, Massagli MP, Clarridge BR, et al. Linguistic and cultural barriers to care: perspectives of Chinese and Vietnamese immigrants. J Gen Intern Med. 2003;18(1):44-52.

144. Wolf PA, D'Agostino RB, Belanger AJ, Kannel WB. Probability of stroke: a risk profile from the Framingham Study. Stroke. 1991;22:312-318.

145. Johnston SC, Rothwell PM, Nguyen-Huynh MN, et al. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet. 2007;369(9558):283-292.

146. Koton S, Rothwell PM. Performance of the ABCD and ABCD2 scores in TIA patients with carotid stenosis and atrial fibrillation. Cerebrovasc Dis. 2007;24(2-3):231-235.

147. Rothwell PM, Giles MF, Flossmann E, et al. A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. Lancet. 2005;366(9479):29-36.

148. Long B, Koyfman A. Best clinical practice: controversies in transient ischemic attack evaluation and disposition in the emergency department. J Emerg Med. 2017;52(3):299-310.

149. Chang BP, Rostanski S, Willey J, et al. Safety and feasibility of a rapid outpatient management strategy for transient ischemic attack and minor stroke: the Rapid Access Vascular Evaluation-Neurology (RAVEN) approach. Ann Emerg Med. 2019;74(4):562-571.

150. Mochari-Greenberger H, Xian Y, Hellkamp AS, et al. Racial/ethnic and sex differences in emergency medical services transport among hospitalized US stroke patients: analysis of the national Get With The Guidelines-Stroke Registry. J Am Heart Assoc. 2015;4:e002099.

151. Centers for Disease Control and Prevention. Prehospital and hospital delays after stroke onset—United States, 2005–2006. MMWR. 2007;56(19):474-478.

152. Jauch EC, Saver JL, Adams HP Jr, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. American Heart Association Stroke Council, Council on Cardiovascular Nursing, Council on Peripheral Vascular Disease, Council on Clinical Cardiology. Stroke. 2013;44:870-947.

153. Acker JE 3rd, Pancioli AM, Crocco TJ, et al. Implementation strategies for emergency medical services within stroke systems of care: a policy statement from the American Heart Association/American Stroke Association Expert Panel on Emergency Medical Services Systems and the Stroke Council. Stroke. 2007;38(11):3097-3115.

154. Kidwell CS, Starkman S, Eckstein M, Weems K, Saver JL. Identifying stroke in the field. Prospective validation of the Los Angeles prehospital stroke screen (LAPSS). Stroke. 2000;31(1):71-76.

155. Christensen H, Fogh Christensen A, Boysen G. Abnormalities on ECG and telemetry predict stroke outcome at 3 months. J Neurol Sci. 2005;234(1-2):99-103.

156. Eberhardt RT, Dhadly M. Giant cell arteritis: diagnosis, management, and cardiovascular implications. Cardiol Rev. 2007;15(2): 55-61.

157. Cervera A, Amaro S, Obach V, Chamorro A. Prevention of ischemic stroke: antithrombotic therapy in cardiac embolism. Curr Drug Targets. 2007;8(7):824-831.

158. Polmear A. Sentinel headaches in aneurysmal subarachnoid hemorrhage: what is the true incidence? A systematic review. Cephalalgia. 2003;23(10):935-941.

159. van der Worp HB, van Gijn J. Clinical practice: acute ischemic stroke. N Engl J Med. 2007;357(6):572-579.

160. Aronson L, Landefeld CS. Examining older people for carotid bruits: listen to your patient, not her neck. J Gen Intern Med. 1998;13(2):140-141.

161. Alexander MR. Hypertension Treatment and Management. Available at https://emedicine.medscape.com/article/241381-treatment#a1156. Last accessed March 9, 2023.

162. Nor AM, Ford GA. Misdiagnosis of stroke. Expert Rev Neurother. 2007;7(8):989-1001.

163. Jauch EC. Ischemic Stroke Differential Diagnoses. Available at https://emedicine.medscape.com/article/1916852-differential. Last accessed March 9, 2023.

164. Frankel MR, Morgenstern LB, Kwiatkowski T, et al. Predicting prognosis after stroke: a placebo group analysis from the National Institute of Neurological Disorders and Stroke rt-PA Stroke Trial. Neurology. 2000;55(7):952-959.

165. National Institute of Neurological Disorders and Stroke. NIH Stroke Scale. Available at https://stroke.nih.gov/resources/scale.htm. Last accessed March 9, 2023.

166. Sarkar S, Ghosh S, Ghosh SK, Collier A. Role of transcranial Doppler ultrasonography in stroke. Postgrad Med J. 2007;83(985):683-689.

167. Demchuk AM, Burgin WS, Christou I, et al. Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator. Stroke. 2001;32(1):89-93.

168. Adams H, Adams R, Del Zoppo G, Goldstein LB. Guidelines for the early management of patients with ischemic stroke: 2005 guidelines update a scientific statement from the Stroke Council of the American Heart Association/American Stroke Association. Stroke. 2005;36:916-923.

169. Essig M, Nikolaou K, Meaney JF. Magnetic resonance angiography of the head and neck vessels. Eur Radiol. 2007;17(Suppl 2):B30-B37.

170. Citron SJ, Wallace RC, Lewis CA, et al. Quality improvement guidelines for adult diagnostic neuroangiography: cooperative study between ASITN, ASNR, and SIR. J Vasc Interv Radiol. 2003;14(9 Pt 2):S257-S262.

171. Culebras A, Kase CS, Masdeu JC, et al. Practice guidelines for the use of imaging in transient ischemic attacks and acute stroke: a report of the Stroke Council, American Heart Association. Stroke. 1997;28:1480-1497.

172. Okumura A, Araki Y, Nishimura Y, et al. The clinical utility of contrast-enhanced 3D MR angiography for cerebrovascular disease. Neurol Res. 2001;23:767-771.

173. Wintermark M, Sanelli PC, Albers GW, et al. A Joint Statement By The American Society of Neurology, The American College of Radiology, and The Society of Neurointerventional Surgery. Imaging Recommendations For Acute Stroke and Transient Ischemic Attack Patients. Charlottesville, VA: ANJR; 2013.

174. Adla T, Adlova R. Multimodality imaging of carotid stenosis. Int J Angiol. 2015;24(3):179-184.

175. Jäger HR, Moore EA, Bynevelt M, et al. Contrast-enhanced MR angiography in patients with carotid artery stenosis: comparison of two different techniques with an unenhanced 2D time-of-flight sequence. Neuroradiology. 2000;42(4):240-248.

176. Meaney JF, Goyen M. Recent advances in contrast-enhanced magnetic resonance angiography. Eur Radiol. 2007;17(Suppl 2):B2-B6.

177. Zhang XH, Liang HM. Systematic review with network meta-analysis. Medicine (Baltimore). 2019;98(30):e16360.

178. Verro P, Tanenbaum LN, Borden NM, Sen S, Eshkar N. CT angiography in acute ischemic stroke: preliminary results. Stroke. 2002;33(1):276-278.

179. Alexandrov AV, Molina CA, Grotta JC, et al. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med. 2004;351:2170-2178.

180. Mullins ME, Schaefer PW, Sorensen AG, et al. CT and conventional and diffusion-weighted MR imaging in acute stroke: study in 691 patients at presentation to the emergency department. Radiology. 2002;224(2):353-360.

181. Rymer MM, Thurtchley D, Summers D, America Brain and Stroke Institute Stroke Team. Expanded modes of tissue plasminogen activator delivery in a comprehensive stroke center increases regional acute stroke interventions. Stroke. 2003;34(6):e58-e60.

182. Frey JL, Jahnke HK, Goslar PW, Partovi S, Flaster MS. tPA by telephone: extending the benefits of a comprehensive stroke center. Neurology. 2005;64(1):154-156.

183. American Heart Association. State Stroke Legislation Increases U.S. Primary Stroke Centers. Available at https://news.heart.org/state-stroke-legislation-increases-u-s-primary-stroke-centers. Last accessed March 9, 2023.

184. Goldstein LB, Hey LA, Laney R. North Carolina stroke prevention and treatment facilities survey. Statewide availability of programs and services. Stroke. 2000;31(1):66-70.

185. Marler JR, Tilley BC, Lu M, et al. Early stroke treatment associated with better outcome: the NINDS rt-PA stroke study. Neurology. 2000;55(11):1649-1655.

186. Hacke W, Donnan G, Fieschi C, et al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet. 2004;363(9411):768-774.

187. Clark WM, Albers GW, Madden KP, Hamilton S, Thrombolytic Therapy in Acute Ischemic Stroke Study Investigators. The rtPA (alteplase) 0-to 6-hour acute stroke trial, part A (A0276g): results of a double-blind, placebo-controlled, multicenter study. Stroke. 2000;31:811-816.

188. Balami JS, Sutherland BA, Buchan AM. Complications associated with recombinant tissue plasminogen activator therapy for acute ischaemic stroke. CNS Neurol Disord Drug Targets. 2013;12(2):155-169.

189. Saver JL. Thrombolytic Therapy in Stroke. Available at https://emedicine.medscape.com/article/1160840-overview. Last accessed March 9, 2023.

190. Lyden PD. Thrombolytic Therapy for Acute Stroke. 3rd ed. New York, NY: Springer; 2015.

191. Chinese Acute Stroke Trial (CAST) Collaborative Group. CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. Lancet. 1997;349(9066):1641-1649.

192. International Stroke Trial Collaborative Group. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. Lancet. 1997;349(9065):1569-1581.

193. Sandercock PA, Counsell C, Tseng MC, Cecconi E. Oral antiplatelet therapy for acute ischaemic stroke. Cochrane Database Syst Rev. 2014;3:CD000029.

194. Fairhead JF, Mehta Z, Rothwell PM. Population-based study of delays in carotid imaging and surgery and the risk of recurrent stroke. Neurology. 2005;65:371-375.

195. January CT, Wann LS, Calkins H, et al. 2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association TASK Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2019;74:104-132.

196. Johnston SC, Amarenco P, Albers GW, et al. Ticagrelor versus aspirin in acute stroke or transient ischemic attack. N Engl J Med. 2016;375:35-43.

197. Wong KSL, Amarenco P, Albers GW, et al. Efficacy and safety of ticagrelor in relation to aspirin use within the week before randomization in the SOCRATES trial. Stroke. 2018;49:1678-1685.

198. U.S. National Library of Medicine. ClinicalTrials.gov. THALES – Acute Stroke or Transient IscHaemic Attack Treated With TicAgreLor and ASA for PrEvention of Stroke and Death. Available at https://clinicaltrials.gov/ct2/show/NCT03354429. Last accessed March 9, 2023.

199. Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ, et al; Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators. Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA.N Engl J Med. 2018;379:215-225.

200. Wang Y, Wang Y, Zhao X, Liu L, Wang D, Wang C, et al; CHANCE Investigators. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013;369:11-19.

201. Diener HC, Bogousslavsky J, Brass LM, Cimminiello C, Csiba L, Kaste M, et al; MATCH Investigators. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 2004;364:331-337.

202. Benavente OR, Hart RG, McClure LA, Szychowski JM, Coffey CS, Pearce LA; SPS3 Investigators. Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. N Engl J Med. 2012;367:817-825.

203. Hankey GJ, Hacke W, Easton JD, Johnston SC, Mas JL, Brennan DM, et al; CHARISMA Trial Investigators. Effect of clopidogrel on the rate and functional severity of stroke among high vascular risk patients: a prespecified substudy of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) trial. Stroke. 2010;41:1679-1683.

204. Sacco RL, Diener HC, Yusuf S, Cotton D, Ounpuu S, Lawton WA, et al; PRoFESS Study Group. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med. 2008;359:1238-1251.

205. Halkes PH, Gray LJ, Bath PM, Diener HC, Guiraud-Chaumeil B, Yatsu FM, et al. Dipyridamole plus aspirin versus aspirin alone in secondary prevention after TIA or stroke: a meta-analysis by risk. J Neurol Neurosurg Psychiatry. 2008;79:1218-1223.

206. Halkes PH, van Gijn J, Kappelle LJ, Koudstaal PJ, Algra A; ESPRIT Study Group. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet. 2006;367:1665-1673.

207. de Vos-Koppelaar NC, Kerkhoff H, de Vogel EM, Zock E, Dieleman HG. The effect of a slower than standard dose escalation scheme for dipyridamole on headaches in secondary prevention therapy of strokes: a randomized, open-label trial (DOSE). Cerebrovasc Dis. 2014;37:285-289.

208. Douen AG, Medic S, Sabih M, Pageau N, Shuaib A. Titrated initiation of acetylsalicylic acid-dipyridamole therapy reduces adverse effects and improves tolerance in patients with stroke. J Stroke Cerebrovasc Dis. 2008;17:356-359.

209. Lipton RB, Bigal ME, Kolodner KB, Gorelick PB, Wilks K, Schoebelock M, et al. Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination. Neurology. 2004;63:1099-1101.

210. Sacco RL, Diener HC, Yusuf S, Cotton D, Ounpuu S, Lawton WA, et al; PRoFESS Study Group. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med. 2008;359:1238-1251.

211. Lapchak PA, Araujo DM. Therapeutic potential of platelet glycoprotein IIb/IIIa receptor antagonists in the management of ischemic stroke. Am J Cardiovasc Drugs. 2003;3(2):87-94.

212. Abciximab Emergent Stroke Treatment Trial (AbESTT) Investigators. Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of a randomized phase 2 trial. Stroke. 2005;36(4):880-890.

213. Adams HP Jr, Effron MB, Torner J, et al. Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial: Abciximab in Emergency Treatment of Stroke Trial (AbESTT-II). Stroke. 2008;39(1):87-99.

214. Ciccone A, Motto C, Abraha I, Cozzolino F, Santilli I. Glycoprotein IIb-IIIa inhibitors for acute ischemic stroke. Cochrane Database Syst Rev. 2014;8(3):CD005208.

215. Birschel P, Ellul J, Barer D. Progressing stroke: towards an internationally agreed definition. Cerebrovasc Dis. 2004;17(2-3):242-252.

216. Hayashi K, Kitagawa N, Takahata H, et al. Endovascular treatment for cervical carotid artery stenosis presenting with progressing stroke: three case reports. Surg Neurol. 2002;58(2):148-154.

217. Du Mesnil de Rochemont R, Sitzer M, Neumann-Haefelin T, Harmjanz A, Berkefeld J. Endovascular recanalization of acute atherothrombotic carotid artery occlusion holds up progressive stroke. Neuroradiology. 2004;46(7):583-586.

218. Adachi K, Sadato A, hayakawa M, Maeda S, Hirose Y. Acute carotid artery stenting in symptomatic high-grade cervical carotid artery stenosis. Neurosurg Rev. 2017;40(1):45-51.

219. Mpotsaris A, Kabbasch C, Borggrefe J, Gontu V, Soderman M. Stenting of the cervical internal carotid artery in acute stroke management: the Karolinska experience. Interv Neuroradiol. 2017;23(2):159-165.

220. Cohen JE, Leker RR, Gotkine M, Gomori M, Ben-Hur T. Emergent stenting to treat patients with carotid artery dissection: clinically and radiologically directed therapeutic decision making. Stroke. 2003;34(12):e254-e257.

221. Cohen JE, Gomori M, Rajz G, et al. Emergent stent-assisted angioplasty of extracranial internal carotid artery and intracranial stent-based thrombectomy in acute tandem occlusive disease: technical considerations. J Neurointerv Surg. 2013;5(5):440-446.

222. Nedeltchev K, Brekenfeld C, Remonda L, et al. Internal carotid artery stent implantation in 25 patients with acute stroke: preliminary results. Radiology. 2005;237(3):1029-1037.

223. Brekenfeld C, Remonda L, Nedeltchev K, et al. Endovascular neuroradiological treatment of acute ischemic stroke: techniques and results in 350 patients. Neurol Res. 2005;27(Supp l):S29-S35.

224. Lutsep HL. Mechanical Thrombolysis in Acute Stroke. Available at https://emedicine.medscape.com/article/1163240-overview. Last accessed March 9, 2023.

225. Berlis A, Lutsep H, Barnwell S, et al. Mechanical thrombolysis in acute ischemic stroke with endovascular photoacoustic recanalization. Stroke. 2004;35(5):1112-1116.

226. Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study; a randomized controlled trial. JAMA. 1999;282(21):2003-2011.

227. Tomsick TA, Khatri P, Jovin T, et al. Equipoise among recanalization strategies. Neurology. 2010;74:1069-1076.

228. Tonarelli SB, Tibbs M, Vazquez G, Lakshminarayan K, Rodriguez GJ, Qureshi AI. Accuracy of the new ICD-9-CM code for "drip-and-ship" thrombolytic treatment in patients with ischemic stroke. J Stroke Cerebrovasc Dis. 2012;21:121-123.

229. Broderick JP, Palesch YY, Demchuk AM, et al. Endovascular therapy after intravenous t-PA versus t-PA alone for stroke. N Engl J Med. 2013;368:893-903.

230. Berkhemer OA, Fransen PS, Beumer D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015;372(1):11-20.

231. Campbell BC, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015;372:1009-1018.

232. Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015;372:1019-1030.

233. Jovin TG, Chamorro A, Cobo E, et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med. 2015;372:2296-2306.

234. Johansson EP, Wester P. Delay from symptoms to carotid endarterectomy. J Intern Med. 2008;263:404-411.

235. Rerkasem K, Rothwell PM. Systematic review of the operative risks of carotid endarterectomy for recently symptomatic stenosis in relation to the timing of surgery. Stroke. 2009;40:e564-e572.

236. Macdonald S. Brain injury secondary to carotid intervention. J Endovasc Ther. 2007;14(2):219-231.

237. Sbarigia E, Toni D, Speziale F, Acconcia MC, Fiorani P. Early carotid endarterectomy after ischemic stroke: the results of a prospective multicenter Italian study. Eur J Vasc Endovasc Surg. 2006;32:229-235.

238. Ballotta E, Meneghetti G, Da Giau G, Manara R, Saladini M, Baracchini C. Carotid endarterectomy within 2 weeks of minor ischemic stroke: a prospective study. J Vasc Surg. 2008;48:595-600.

239. Huber R, Müller BT, Seitz RJ, Siebler M, Mödder U, Sandmann W. Carotid surgery in acute symptomatic patients. Eur J Vasc Endovasc Surg. 2003;25:60-67.

240. Welsh S, Mead G, Chant H, Picton A, O'Neill PA, McCollum CN. Early carotid surgery in acute stroke: a multicentre randomised pilot study. Cerebrovasc Dis. 2004;18:200-205.

241. Paty PS, Darling RC 3rd, Feustel PJ, et al. Early carotid endarterectomy after acute stroke. J Vasc Surg. 2004;39:148-154.

242. Vellimana AK, Kadkhodayan Y, Rich KM, et al. Symptomatic patients with intraluminal carotid artery thrombus: outcome with a strategy of initial anticoagulation. J Neurosurg. 2013;118(1):34-41.

243. Langhorne P, Duncan P. Does the organization of postacute stroke care really matter? Stroke. 2001;32(1):268-274.

244. Miller EL, Murray L, Richards L, et al. Comprehensive overview of nursing and interdisciplinary rehabilitation care of the stroke patient: a scientific statement from the American Heart Association. Stroke. 2010;41:2402-2448.

245. Teasell R, Foley N, Bhogal SK, Speechley M. Outpatient Stroke Rehabilitation. Available at http://www.ebrsr.com/evidence-review/7-outpatient-stroke-rehabilitation. Last accessed March 9, 2023.

246. Kalra L, Langhorne P. Facilitating recovery: evidence for organized stroke care. J Rehabil Med. 2007;39(2):97-102.

247. Deutsch A, Granger CV, Heinemann AW, et al. Poststroke rehabilitation: outcomes and reimbursement of inpatient rehabilitation facilities and subacute rehabilitation programs. Stroke. 2006;37:1477-1482.

248. Maulden SA, Gassaway J, Horn SD, Smout RJ, DeJong G. Timing of initiation of rehabilitation after stroke. Arch Phys Med Rehabil. 2005;86(Suppl 2):S34-S40.

249. Prvu Bettger JA, Stineman MG. Effectiveness of multidisciplinary rehabilitation services in postacute care: state-of-the-science: a review. Arch Phys Med Rehabil. 2007;88:1523-1534.

250. Buntin MB, Garten AD, Paddock S, Saliba D, Totten M, Escarce JJ. How much is postacute care use affected by its availability? Health Serv Res. 2005;40:413-434.

251. 251. Report to the Congress: Variation and Innovation in Medicare. Washington, DC: Medicare Payment Advisory Commission (MedPAC); 2003.

252. 252. Report to the Congress: Medicare Payment Policy. Washington, DC: Medicare Payment Advisory Commission (MedPAC); 2003.

253. Ellis C, Breland HL, Egede LE. Racial/ethnic differences in utilization of post-stroke rehabilitation services: a systematic review.Ethn Dis. 2008;18:365-372.

254. Finlayson M. Changes predicting long-term care use among the oldest-old. Gerontologist. 2002;42:443-453.

255. Bhandari VK, Kushel M, Price L, Schillinger D. Racial disparities in outcomes of inpatient stroke rehabilitation. Arch Phys Med Rehabil. 2005;86(11):2081-2086.

256. Stroke Unit Trialists' Collaboration. Organised inpatient (stroke unit) care for stroke. Cochrane Database Syst Rev. 2013;(9):CD000197.

257. White JH, Alston MK, Marquez JL, et al. Community-dwelling stroke survivors: function is not the whole story with quality of life. Arch Phys Med Rehabil. 2007;88(9):1140-1146.

258. Langhorne P, Cadilhac D, Feigin V, Grieve R, Liu M. How should stroke services be organised? Lancet Neurol. 2002;1(1):62-68.

259. Glass TA, Matchar DB, Belyea M, Feussner JR. Impact of social support on outcome in first stroke. Stroke. 1993;24(1):64-70.

260. Forster A, Brown L, Smith J, et al. Information provision for stroke patients and their caregivers. Cochrane Database Syst Rev. 2012;11:CD0011919.

261. Tsouna-Hadjis E, Vemmos KN, Zakopoulos N, Stamatelopoulos S. First-stroke recovery process: the role of family social support.Arch Phys Med Rehabil. 2000;81(7):881-887.

262. Scottish Intercollegiate Guidelines Network. Management of Patients with Stroke: Rehabilitation, Prevention and Management of Complications, and Discharge Planning. A National Clinical Guideline. Edinburgh: Scottish Intercollegiate Guidelines Network; 2010.

263. Chen Y, Lu J, Wong KS, Mok VC, Ungvari GS, Tang WK. Health-related quality of life in the family caregivers of stroke survivors.Int J Rehabil Res. 2010;33:232-237.

264. Bergersen H, Froslie KF, Stibrant Sunnerhagen K, Schanke AK. Anxiety, depression, and psychological well-being 2 to 5 years poststroke. J Stroke Cerebrovasc Dis. 2010;19:364-369.

265. Oupra R, Griffiths R, Pryor J, Mott S. Effectiveness of Supportive Educative Learning programme on the level of strain experienced by caregivers of stroke patients in Thailand. Health Soc Care Comm. 2010;18:10-20.

266. Choi-Kwon S, Mitchell PH, Veith R, et al. Comparing perceived burden for Korean and American informal caregivers of stroke survivors. Rehabil Nurs. 2009;34:141-150.

267. Smith SD, Gignac MA, Richardson D, Cameron JI. Differences in the experiences and support needs of family caregivers to stroke survivors: does age matter? Top Stroke Rehabil. 2008;15:593-601.

268. Perrin PB, Johnston A, Vogel B, et al. A culturally sensitive Transition Assistance Program for stroke caregivers: examining caregiver mental health and stroke rehabilitation. J Rehabil Res Dev. 2010;47:605-617.

269. Lurbe-Puerto K, Leandro ME, Baumann M. Experiences of caregiving, satisfaction of life, and social repercussions among family caregivers, two years post-stroke. Soc Work Health Care. 2012;51:725-742.

270. Bucki B, Spitz E, Baumann M. Emotional and social repercussions of stroke on patient-family caregiver dyads: analysis of diverging attitudes and profiles of the differing dyads. PLoS One. 2019;14(4):e0215425.

271. Adams HP Jr, Davis PH, Leira EC, et al. Baseline NIH Stroke Scale score strongly predicts outcome after stroke: a report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Neurology. 1999;53(1):126-131.

272. Schlegel D, Kolb SJ, Luciano JM, et al. Utility of the NIH Stroke Scale as a predictor of hospital disposition. Stroke. 2003;34(1):134-137.

273. Hage V. The NIH stroke scale: a window into neurological status. Nurs Spectrum. 2011;24(15):44-49.

274. Schlegel DJ, Tanne D, Demchuk AM, Levine SR, Kasner SE, the Multicenter rt-PA Stroke Survey Group. Prediction of hospital disposition after thrombolysis for acute ischemic stroke using the National Institutes of Health Stroke Scale. Arch Neurol. 2004;61(7):1061-1064.

275. Yoo AJ, Barak ER, Copen WA, et al. Combining acute diffusion-weighted imaging and mean transmit time lesion volumes with national institutes of Health Stroke Scale Score improves the prediction of acute stroke outcome. Stroke. 2010;41(8):1728-1735.

276. Glymour MM, Berkman LF, Ertel KA, Fay ME, Glass TA, Furie KL. Lesion characteristics, NIH stroke scale, and functional recovery after stroke. Am J Phys Med Rehabil. 2007;86(9):725-733.

277. Peters HT, White SE, Page SJ. The National Institutes of Health Stroke Scale lacks validity in chronic hemiparetic stroke. J Stroke Cerebrovasc Dis. 2015;24(10):2207-2212.

278. Planton M, Peiffer S, Albucher J, et al. Neuropsychological outcome after a first symptomatic ischaemic stroke with 'good recovery'.Eur J Neurol. 2012;19(2):212-219.

279. Van Zandvoort MJ, Kappelle LJ, Algra A, De Haan EH. Decreased capacity for mental effort after single supratentorial lacunar infarct may affect performance in everyday life. J Neurol Neurosurg Psychiatry. 1998;65(5):697-702.

280. Nijland RH, van Wegen EE, Harmeling-van der Wel BC, Kwakkel G, EPOS Investigators. Presence of finger extension and shoulder abduction within 72 hours after stroke predicts functional recovery: early prediction of functional outcome after stroke: the EPOS cohort study. Stroke. 2010;41(4):745-750.

281. Ghaziani E, Couppe C, Siersma V, et al. Easily conducted tests during the first week post-stroke can aid the prediction of arm functioning at 6 months. Front Neurol. 2020;10:1371.

282. Kalra L, Evans A, Perez I, et al. Training care givers of stroke patients: randomised controlled trial. BMJ. 2004;328(7448):1099.

283. Teasell R, Mehta S, Pereira S, McIntyre A, Janzen S, Allen L, Lobo L, Viana R. Time to rethink long-term rehabilitation management of stroke patients. Top Stroke Rehabil. 2012;19:457-462.

284. Ferrarello F, Baccini M, Rinaldi LA, et al. Efficacy of physiotherapy interventions late after stroke: a meta-analysis. J Neurol Neurosurg Psychiatry. 2011;82:136-143.

285. Visser-Meily A, Post M, Gorter JW, Berlekom SB, Van Den Bos T, Lindeman E. Rehabilitation of stroke patients needs a family-centered approach. Disabil Rehabil. 2006;28(24):1557-1561.

286. Langhorne P, Stott DJ, Robertson L, et al. Medical complications after stroke: a multicenter study. Stroke. 2000;31(6):1223-1229.

287. National Pressure Ulcer Advisory Panel. Pressure ulcer prevalence, cost, and risk assessment: consensus development conference statement. Decubitus. 1989;2(2):24-28.

288. National Pressure Ulcer Advisory Panel. Pressure Injury Stages: NPUAP Pressure Injury Stages. Available at https://npiap.com/page/PressureInjuryStages. Last accessed March 9, 2023.

289. Walker P. Management of pressure ulcers. Oncology. 2001;15(11):1499-1508, 1511.

290. Groeneveld A, Anderson M, Allen S, et al. The prevalence of pressure ulcers in a tertiary care pediatric and adult hospital. J Wound Ostomy Continence Nurs. 2004;31(3):108-120.

291. Berlowitz DR, Brienza DM. Are all pressure ulcers the result of deep tissue injury? A review of the literature. Ostomy Wound Manage. 2007;53(10):34-38.

292. Institute for Clinical Systems Improvement. Pressure Ulcer Prevention and Treatment Protocol: Health Care Protocol. Bloomington, MN; Institute for Clinical Systems Improvement (ICSI); 2012.

293. Edlich RF, Winters KL, Woodard CR, et al. Pressure ulcer prevention. J Long Term Eff Med Implants. 2004;14(4):285-304.

294. Redelings MD, Lee NE, Sorvillo F. Pressure ulcers: more lethal than we thought? Adv Skin Wound Care. 2005;18(7):367-372.

295. Edsberg LE, Black JM, Goldberg M, McNichol L, Moore L, Sieggreen M. Revised National Pressure Ulcer Advisory Panel pressure injury staging system: revised pressure injury staging system. J Wound Ostomy Continence Nurs. 2016;43(6):585-597.

296. Malhotra S, Pandyan AD, Rosewilliam S, Roffe C, Hermens H. Spasticity and contractures at the wrist after stroke: time course of development and their association with functional recovery of the upper limb. Clin Rehabil. 2011;25:184-191.

297. Sackley C, Brittle N, Patel S, et al. The prevalence of joint contractures, pressure sores, painful shoulder, other pain, falls, and depression in the year after a severely disabling stroke. Stroke. 2008;39:3329-3334.

298. Wells PS, Anderson DR, Bormanis J, et al. Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet. 1997;350(9094):1795-1798.

299. Qaseem A, Snow V, Barry P, et al. Current diagnosis of venous thromboembolism in primary care: a clinical practice guideline from the American Academy of Family Physicians and the American College of Physicians. Ann Fam Med. 2007;5(1):57-62.

300. Muir KW, Watt A, Baxter G, Grosset DG, Lees KR. Randomized trial of graded compression stockings for prevention of deep-vein thrombosis after acute stroke. QJM. 2000;93(6):359-364.

301. Naccarato M, Chiodo Grandi F, Dennis M, Sandercock PA. Physical methods for preventing deep vein thrombosis in stroke. Cochrane Database Syst Rev. 2010;8:CD001922.

302. Gould MK, Garcia DA, Wren SM, et al. Prevention of VTE in nonorthopedic surgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(Suppl 1):e-227S-e277S.

303. Martino R, Foley N, Bhogal S, Diamant N, Speechley M, Teasell R. Dysphagia after stroke: incidence, diagnosis, and pulmonary complications. Stroke. 2005;36(12):2756-2763.

304. Bath PM, Lee HS, Everton LF. Swallowing therapy for dysphagia in acute and subacute stroke. Cochrane Database Syst Rev. 2018;10:CD000323.

305. Perry L, Love CP. Screening for dysphagia and aspiration in acute stroke: a systematic review. Dysphagia. 2001;16(1):7-18.

306. Falsetti P, Acciai C, Palilla R, et al. Oropharyngeal dysphagia after stroke: incidence, diagnosis, and clinical predictors in patients admitted to a neurorehabilitation unit. J Stroke Cerebrovasc Dis. 2009;18(5):329-335.

307. Zhang JH, Wang D, Liu M. Overview of systematic reviews and meta-analyses of acupuncture for stroke. Neuroepidemiology. 2014;42(1):50-58.

308. Kolominsky-Rabas PL, Hilz MJ, Neundoerfer B, Heuschmann PU. Impact of urinary incontinence after stroke: results from a prospective population-based stroke register. Neurourol Urodyn. 2003;22(4):322-327.

309. Thomas LH, Coupe J, Cross LD, Tan AL, Watkins CL. Interventions for treating urinary incontinence after stroke in adults.Cochrane Database Syst Rev. 2019;2:CD004462.

310. Pettersen R, Haig Y, Nakstad PH, Wyller TB. Subtypes of urinary incontinence after stroke: relation to size and location of cerebrovascular damage. Age Ageing. 2008;37(3):324-327.

311. Harari D, Coshall C, Rudd AG, Wolfe CDA. New-onset fecal incontinence after stroke: prevalence, natural history, risk factors, and impact. Stroke. 2003;34(1):144-150.

312. Vasavada SP. Urinary Incontinence. Available at http://emedicine.medscape.com/article/452289-overview. Last accessed March 9, 2023.

313. Stroke Foundation. Incontinence after Stroke Fact Sheet. Available at https://strokefoundation.org.au/what-we-do/for-survivors-and-carers/after-stroke-factsheets/incontinence-after-stroke-fact-sheet. Last accessed March 9, 2023.

314. Eustice S, Roe B, Paterson J. Prompted voiding for the management of urinary incontinence in adults. Cochrane Database Syst Rev. 2000;(2):CD002113.

315. Heart and Stroke Foundation of Ontario, Registered Nurses' Association of Ontario. Stroke Assessment across the Continuum of Care. Toronto: Heart and Stroke Foundation of Ontario and Registered Nurses' Association of Ontario; 2005.

316. Robain G, Chennevelle JM, Petit F, Piera JB. Incidence of constipation after recent vascular hemiplegia: a prospective cohort of 152 patients. Rev Neurol (Paris). 2002;158:589-592.

317. Winge K, Rasmussen D, Werdelin LM. Constipation in neurological diseases. J Neurol Neurosurg Psychiatry. 2003;74:13-19.

318. Chatoor DR, Taylor SJ, Cohen CR, Emmanuel AV. Faecal incontinence. Br J Surg. 2007;94(2):134-144.

319. Batchelor F, Hill K, Mackintosh S, Said C. What works in falls prevention after stroke? A systematic review and meta-analysis. Stroke. 2010;41:1715-1722.

320. Tilson JK, Wu SS, Cen SY, et al. Characterizing and identifying risk for falls in the LEAPS study: a randomized clinical trial of interventions to improve walking poststroke. Stroke. 2012;43(2):446-452.

321. Jørgensen L, Engstad T, Jacobsen BK. Higher incidence of falls in long-term stroke survivors than in population controls: depressive symptoms predict falls after stroke. Stroke. 2002;33(2):542-547.

322. Czernuszenko A. Risk factors for falls in post-stroke patients treated in a neurorehabilitation ward. Neurol Neurochir Pol. 2007;41(1):28-35.

323. Andersson AG, Kamwendo K, Seiger A, Appelros P. How to identify potential fallers in a stroke unit: validity indexes of 4 test methods. J Rehabil Med. 2006;38(3):186-191.

324. Teasell R, McRae M, Foley N, Bhardwaj A. The incidence and consequences of falls in stroke patients during inpatient rehabilitation: factors associated with high risk. Arch Phys Med Rehabil. 2002;83(3):329-333.

325. Berg KO, Wood-Dauphinee SL, Williams JI, Maki B. Measuring balance in the elderly: validation of an instrument. Can J Public Health. 1992;83(Suppl 2):S7-S11.

326. Hollands KL, Pelton TA, Tyson SF, Hollands MA, van Vliet PM. Interventions for coordination of walking following stroke: systematic review. Gait Posture. 2012;35(3):349-359.

327. Beauchet O, Annweiler C, Dubost V, et al. Stops walking when talking: a predictor of falls in older adults? Eur J Neurol. 2009;16(7):786-795.

328. Smith J, Forster A, Young J. Use of the "STRATIFY" falls risk assessment in patients recovering from acute stroke. Age Ageing. 2006;35(2):138-143.

329. Andersen G, Vestergaard K, Ingeman-Nielsen M, Jensen TS. Incidence of central post-stroke pain. Pain. 1995;61(2):187-193.

330. Thom T, Haase N, Rosamond W, et al. Heart disease and stroke statistics—2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2006;113(6):e85-e151.

331. Frese A, Husstedt IW, Ringelstein EB, Evers S. Pharmacologic treatment of central post-stroke pain. Clin J Pain. 2006;22(3):252-260.

332. The Center for Outcome Measurement in Brain Injury. Introduction to the FIM. Available at http://www.tbims.org/combi/FIM. Last accessed March 9, 2023.

333. Ottenbacher KJ, Hsu Y, Granger CV, Fiedler RC. The reliability of the functional independence measure: a quantitative review. Arch Phys Med Rehabil. 1996;77(12):1226-1232.

334. Nourhashémi F, Andrieu S, Gillette-Guyonnet S, Vellas B, Albarède JL, Grandjean H. Instrumental activities of daily living as a potential marker of frailty: a study of 7364 community-dwelling elderly women (the EPIDOS study). J Gerontol A Biol Sci Med Sci. 2001;56(7):M448-M453.

335. Nys GM, Van Zandvoort MJ, De Kort PL, et al. Domain-specific cognitive recovery after first-ever stroke: a follow-up study of 111 cases. J Int Neuropsychol Soc. 2005;11(7):795-806.

336. Chung CS, Pollock A, Campbell T, Durward BR, Hagen S. Cognitive rehabilitation for executive dysfunction in adults with stroke or other adult non-progressive acquired brain damage. Cochrane Database Syst Rev. 2013;4:CD008391.

337. Kalashnikova LA, Zueva YV, Pugacheva OV, Korsakova NK. Cognitive impairments in cerebellar infarcts. Neurosci Behav Physiol. 2005;35(8):773-779.

338. Vallar G, Ronchi R. Anosognosia for motor and sensory deficits after unilateral brain damage: a review. Restor Neurol Neurosci. 2006;24(4-6):247-257.

339. Patel MD, Coshall C, Rudd AG, Wolfe CD. Cognitive impairment after stroke: clinical determinants and its associations with long-term stroke outcomes. J Am Geriatr Soc. 2002;50(4):700-706.

340. Rasquin SM, Verhey FR, Lousberg R, Lodder J. Cognitive performance after first ever stroke related to progression of vascular brain damage: a 2 year follow up CT scan study. J Neurol Neurosurg Psychiatry. 2005;76(8):1075-1079.

341. de Haan EH, Nys GM, Van Zandvoort MJ. Cognitive function following stroke and vascular cognitive impairment. Curr Opin Neurol. 2006;19(6):559-564.

342. Patel MD, McKevitt C, Lawrence E, Rudd AG, Wolfe CD. Clinical determinants of long-term quality of life after stroke. Age Ageing. 2007;36(3):316-322.

343. Erkinjuntti T. Vascular cognitive deterioration and stroke. Cerebrovasc Dis. 2007;24(Suppl 1):189-194.

344. Edwards DF, Hahn MG, Baum CM, Perlmutter MS, Sheedy C, Dromerick AW. Screening patients with stroke for rehabilitation needs: validation of the post-stroke rehabilitation guidelines. Neurorehabil Neural Repair. 2006;20(1):42-48.

345. Buxbaum LJ, Ferraro MK, Veramonti T, et al. Hemispatial neglect: subtypes, neuroanatomy, and disability. Neurology. 2004;62(5):749-756.

346. Townend E, Brady M, McLaughlan K. A systematic evaluation of the adaptation of depression diagnostic methods for stroke survivors who have aphasia. Stroke. 2007;38(11):3076-3083.

347. American Speech-Language-Hearing Association. Aphasia. Available at https://www.asha.org/public/speech/disorders/aphasia. Last accessed March 9, 2023.

348. Crinion JT, Leff AP. Recovery and treatment of aphasia after stroke: functional imaging studies. Curr Opin Neurol. 2007;20(6):667-673.

349. American Speech-Language-Hearing Association. Preferred Practice Patterns for the Profession of Speech-Language Pathology. Available at https://www.asha.org/policy/pp2004-00191. Last accessed March 9, 2023.

350. Cicerone KD, Dahlberg C, Malec JF, et al. Evidence-based cognitive rehabilitation: updated review of the literature from 1998 through 2002. Arch Phys Med Rehabil. 2005;86(8):1681-1692.

351. Paolucci S. Epidemiology and treatment of post-stroke depression. Neuropsychiatr Dis Treat. 2008;4(1):145-154.

352. Barker-Collo SL. Depression and anxiety 3 months post stroke: prevalence and correlates. Arch Clin Neuropsychol. 2007;22(4):519-531.

353. Bienenfeld D, Screening Tests for Depression. Available at https://emedicine.medscape.com/article/1859039-overview. Last accessed March 9, 2023.

354. Mini-Mental State Examination (MMSE). Available at https://cgatoolkit.ca/Uploads/ContentDocuments/MMSE.pdf. Last accessed March 9, 2023.

355. Arroll B, Goodyear-Smith F, Crengle S, et al. Validation of PHQ-s and PHQ-0 to screen for major depression in the primary care population. Ann Fam Med. 2010;8(4):348-353.

356. Leppävuori A, Pohjasvaara T, Vataja R, Kaste M, Erkinjuntti T. Generalized anxiety disorders three to four months after ischemic stroke. Cerebrovasc Dis. 2003;16(3):257-264.

357. Rosen HJ, Cummings J. A real reason for patients with pseudobulbar affect to smile. Ann Neurol. 2007;61(2):92-96.

358. Ramasubbu R. Cerebrovascular effects of selective serotonin reuptake inhibitors: a systematic review. J Clin Psychiatry. 2004;65(12):1642-1653.

359. Legg LA, Tilney R, Hsieh CF, et al. Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery. Cochrane Database Syst Rev. 2019;11:CD009286.

360. Billinger SA, Arena R, Bernhardt J, et al. Physical activity and exercise recommendations for stroke survivors: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(8):2532-2553.

361. Michael KM, Allen JK, Macko RF. Reduced ambulatory activity after stroke: the role of balance, gait, and cardiovascular fitness. Arch Phys Med Rehabil. 2005;86(8):1552-1556.

362. Wittenberg GF, Chen R, Ishii K, et al. Constraint-induced therapy in stroke: magnetic-stimulation motor maps and cerebral activation. Neurorehabil Neural Repair. 2003;17(1):48-57.

363. American Association of Cardiovascular and Pulmonary Rehabilitation. Guidelines for Cardiac Rehabilitation and Secondary Prevention Programs. 5th ed. Champaign, IL: Human Kinetics Publishers; 2013.

364. American College of Sports Medicine, Chodzko-Zajiko WJ, Proctor DN, et al. American College of Sports Medicine position stand: exercise and physical activity for older adults. Med Sci Sports Exerc. 2009;41(7):1510-1530.

365. Thompson PD, Buchner D, Piña IL, et al. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation. 2003;107(24):3109-3116.

366. Morris JH, Macgillivray S, Macfarlane S. Interventions to promote long-term participation in physical activity after stroke: a systematic review of the literature. Arch Phys Med Rehabil. 2014;95(5):956-967.

367. Coupar F, Pollock A, Legg LA, Sackley C, van Vliet P. Home-based therapy programmes for upper limb functional recovery following stroke. Cochrane Database Syst Rev. 2012;5:CD006755.

368. Schwartz I, Meiner Z. The influence of locomotor treatment using robotic body-weight-supported treadmill training on rehabilitation outcome of patients suffering neurological disorders. Harefuah. 2013;152(3):166-171.

369. Macko RF, Smith GV, Dobrovolny CL, Sorkin JD, Goldberg AP, Silver KH. Treadmill training improves fitness reserve in chronic stroke patients. Arch Phys Med Rehabil. 2001;82(7):879-884.

370. Yang YR, Wang RY, Lin KH, Chu MY, Chan RC. Task-oriented progressive resistance strength training improves muscle strength and functional performance in individuals with stroke. Clin Rehabil. 2006;20(10):860-870.

371. Stewart JC, Yeh SC, Jung Y, et al. Intervention to enhance skilled arm and hand movements after stroke: a feasibility study using a new virtual reality system. J Neuroeng Rehabil. 2007;4:21.

372. Brunner I, Skouen JS, Hofstad H, et al. Virtual reality training for upper extremity in subacute stroke (VIRTUES): a multicenter RCT. Neurology. 2017;89(24):2413-2421.

373. Schuster-Amft C, Eng K, Suica Z, et al. Effect of a four-week virtual reality-based training versus conventional therapy on upper limb motor function after stroke: a multicenter parallel group randomized trial. PLoS One. 2018;13(10):e00204455.

374. Jamieson DG. Secondary prevention of ischemic stroke: evolution from a stepwise to a risk stratification approach to care. Dis Manag. 2007;10(5):273-284.

375. Hankey GJ. Long-term outcome after ischaemic stroke/transient ischaemic attack. Cerebrovasc Dis. 2003;16(Suppl 1):14-19.

376. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342(3):145-153.

377. Lawes CM, Bennett DA, Feigin VL, Rodgers A. Blood pressure and stroke: an overview of published reviews. Stroke. 2004;35(4):1024-1033.

378. Rashid P, Leonardi-Bee J, Bath P. Blood pressure reduction and secondary prevention of stroke and other vascular events: a systematic review. Stroke. 2003;34(11):2741-2748.

379. Petty GW, Brown RD Jr, Whisnant JP, Sicks JD, O'Fallon WM, Wiebers DO. Survival and recurrence after first cerebral infarction: a population-based study in Rochester, Minnesota, 1975 through 1989. Neurology. 1998;50(1):208-216.

380. Hillen T, Coshall C, Tilling K, Rudd AG, McGovern R, Wolfe CD. Cause of stroke recurrence is multifactorial: patterns, risk factors, and outcomes of stroke recurrence in the South London Stroke Register. Stroke. 2003;34(6):1457-1463.

381. Heart Outcomes Prevention Evaluation Study Investigators. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Lancet. 2000;355(9200):253-259.

382. Burns DM. Epidemiology of smoking-induced cardiovascular disease. Prog Cardiovasc Dis. 2003;46:11-29.

383. Fagerstrom K. The epidemiology of smoking: health consequences and benefits of cessation. Drugs. 2002;62(Suppl 2):1-9.

384. You RX, Thrift AG, McNeil JJ, Davis SM, Donnan GA. Ischemic stroke risk and passive exposure to spouses' cigarette smoking: Melbourne Stroke Risk Factor Study (MERFS) Group. Am J Public Health. 1999;89(4):572-575.

385. Tobacco Use and Dependence Guideline Panel. Treating Tobacco Use and Dependence: 2008 Update. Rockville, MD: U.S. Department of Health and Human Services, Public Health Service; 2008.

386. Reynolds K, Lewis B, Nolen JD, Kinney GL, Sathya B, He J. Alcohol consumption and risk of stroke: a meta-analysis. JAMA. 2003;289(5):579-588.

387. Thijs VN, Albers GW. Symptomatic intracranial atherosclerosis: outcome of patients who fail antithrombotic therapy. Neurology. 2000;55(4):490-497.

388. Lopes RD, Crowley MJ, Shah BR, et al. Stroke Prevention in Atrial Fibrillation: Comparative Effectiveness Review No. 123. Rockville, MD: Agency for Healthcare Research and Quality; 2013.

389. You JJ, Singer DE, Howard PA, et al. Antithrombotic therapy for atrial fibrillation. Antithrombotic therapy and prevention of thrombosis, 9th ed. American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141 (2 Suppl):e531S-e575S.

390. Lexicomp Online. Available at http://online.lexi.com. Last accessed March 9, 2023.

391. Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361(12):1139-51.

392. Drugs@FDA. Available at https://www.accessdata.fda.gov/scripts/cder/daf. Last accessed March 9, 2023.

393. Uchino K, Hernandez AV. Dabigatran association with higher risk of acute coronary events: meta-analysis of noninferiority randomized controlled trials. Arch Intern Med. 2012;172(5):397-402.

394. Howard PA, New oral anticoagulants for stroke prevention in atrial fibrillation: more choices bring more challenges. Hosp Pharm. 2013;48(5):366-371.

395. Wann LS, Curtis AB, Ellenbogen KA, et al. 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (update on dabigatran): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2011;123(10):1144-1150.

396. LaMori JC, Mody SH, Gross HJ, et al. Burden of comorbidities among patients with atrial fibrillation. Ther Adv Cardiovasc Dis. 2013;7(2):53-62.

397. U.S. Food and Drug Administration. FDA Approves First-of-Its-Kind Stroke Rehabilitation System. Available at https://www.fda.gov/news-events/press-announcements/fda-approves-first-its-kind-stroke-rehabilitation-system. Last accessed March 9, 2023.

398. Amarenco P, Lavallée PC, Monteiro Tavares L, et al. Five-year risk of stroke after TIA or minor ischemic stroke. N Engl J Med. 2018;378:2182-2190.

399. Amarenco P. Transient ischemic attack. N Engl J Med 2020;382:1933-1941.

400. Oshunbade AA, Yimer WK, Valle KA, et al. Cigarette smoking and incident stroke in Blacks of the Jackson Heart Study. JAMA. 2020;9(12):e014990,

401. George MG. Risk factors for ischemic stroke in younger adults. Stroke. 2020;51:729-735.

402. Amin HP, Madsen TE, Bravata DM, et al. Diagnosis, workup, risk reduction of transient ischemic attack in the emergency department setting: a scientific statement from the American Heart Association. Stroke. 2023;54;e109-e121.