1. Beveridge RN. Crossing the Healthcare Chasm: Health Care Trends 2011–2015. Available at http://journals.sagepub.com/doi/abs/10.1177/2150133510395494. Last accessed May 24, 2024.
2. Federal Interagency Forum on Aging-Related Statistics. Older Americans 2020: Key Indicators of Well-Being. Laurel, MD: U.S. Government Printing Office; 2020.
3. ADA. Aging and Dental Health. Available at https://www.ada.org/en/resources/ada-library/oral-health-topics/aging-and-dental-health#. Last accessed May 24, 2024.
4. Centers for Disease Control and Prevention. Living with a Chronic Condition. Available at https://www.cdc.gov/chronic-disease/living-with/index.html. Last accessed May 24, 2024.
5. U.S. Department of Health and Human Services. 2021 Profile of Older Americans. Available at https://acl.gov/sites/default/files/Profile%20of%20OA/2021%20Profile%20of%20OA/2021ProfileOlderAmericans_508.pdf. Last accessed May 24, 2024.
6. U.S. Department of Health and Human Services. Oral Health in America: A Report of the Surgeon General. Rockville, MD: U.S. Department of Health and Human Services, National Institute of Dental and Craniofacial Research, National Institutes of Health; 2000.
7. Arora SA, Ahuja P. Periodontal disease: a possible risk factor for adverse pregnancy outcomes. JIDA. 2011;5(4):552-554.
9. World Health Organization. Oral Health. Available at https://www.who.int/health-topics/oral-health/#tab=tab_1. Last accessed May 24, 2024.
10. Barnett ML. The oral-systemic disease connection: an update for the practicing dentist. J Am Dent Assoc. 2006;137(Suppl 2):S5-S6.
11. Mayo Clinic. Periodontitis: Symptoms and Causes. Available at https://www.mayoclinic.org/diseases-conditions/periodontitis/symptoms-causes/syc-20354473. Last accessed May 24, 2024.
12. Pussinen PJ, Alfthan G, Rissanen H, et al. Antibodies to periodontal pathogens and stroke risk. Stroke. 2004;35(9):2020-2023.
13. Veloso TR, Amiquet M, Rousson V, et al. Induction of experimental endocarditis by continuous low-grade bacteremia mimicking spontaneous bacteremia in humans. Infect Immun. 2011;79(5):2006-2011.
14. Misra S, Singh A, Singh N. Periodontal infection as a risk factor for atherosclerosis. Indian J Dent Sci. 2012;1(4):94-96.
15. Meisel P, Kohlmann T, Wallaschofski H, Kroemer HK, Kocher T. Cholesterol, C reactive-proteins, and periodontitis: HMG-CoA-reductase inhibitors (statins) as effect modifiers. ISRN Dent. 2011;2011:125168.
16. Guo Y, Nguyen KA, Potempa J. Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins. Periodontol 2000. 2010;54(1):15-44.
17. European Society of Cardiology. Press Release: Periodontal Disease Associated with Cardiovascular Risk in Large Multicentre Study. Available at https://www.escardio.org/The-ESC/Press-Office/Press-releases/Periodontal-disease-associated-with-cardiovascular-risk-in-large-multicentre-stu. Last accessed May 24, 2024.
18. Martin SS, Aday AW, Almarzooq ZI, et al. 2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association. Circulation. 2024;149(8):e347-e913.
19. James PA, Oparil S, Carter BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311(5):507-520.
20. Whelton PK, Carey RM, Aranow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2018;71(6):e127-e248.
21. National Heart, Lung, and Blood Institute. What is High Blood Pressure? Available at https://www.nhlbi.nih.gov/health/high-blood-pressure. Last accessed May 24, 2024.
22. Mayo Clinic. Secondary Hypertension. Available at https://www.mayoclinic.org/diseases-conditions/secondary-hypertension/symptoms-causes/syc-20350679. Last accessed May 24, 2024.
23. Centers for Disease Control and Prevention, National Center for Health Statistics. Interactive Symmary Health Statistics for Adults. Available at https://wwwn.cdc.gov/NHISDataQueryTool/SHS_adult/index.html. Last accessed May 24, 2024.
24. Sharma S, Sridhar S, McIntosh A, et al. periodontal therapy and treatment of hypertension-alternative to the pharmacological approach. A systematic review and meta-analysis. Pharmacol Res. 2021;166:105511.
25. Kim JY, Kenney EB. Management of Hypertension in Clinical Dentistry. Available at https://www.scribd.com/document/79055724/Management-of-Hypertension-in-Clinical-Dentistry#scribd. Last accessed May 24, 2024.
26. Wynn RL, Meiller TF, Crossley HL. Drug Information Handbook for Dentistry. 25th ed. Hudson, OH: Lexi-Comp; 2019.
27. Mayo Clinic. Angiotensin-Converting Enzyme (ACE) Inhibitors. Available at https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/ace-inhibitors/art-20047480. Last accessed May 24, 2024.
28. Tsao CW, Aday AW, Almarzooq ZI, et al. Heart disease and stroke statistics – 2023 update: a report from the American Heart Association. Circulation. 2023;147(8):e93-e621.
29. Curtin SC, Tejada-Vera B, Bastian BA. Deaths: leading causes for 2020. Natl Vital Statictics Rep. 2023;72(13):1-114.
30. Olson KR. Warfarin and Superwarfarin Toxicity. Available at https://emedicine.medscape.com/article/821038-overview. Last accessed May 24, 2024.
31. Cucchiara BL, Messé SR. Long-term Antithrombotic Therapy for Secondary Prevention of Ischemic Stroke. Available at https://www.uptodate.com/contents/long-term-antithrombotic-therapy-for-the-secondary-prevention-of-ischemic-stroke. Last accessed May 24, 2024.
32. Taber's Online. International Normalized Ratio. Available at https://www.tabers.com/tabersonline/view/Tabers-Dictionary/751508/all/international_normalized_ratio. Last accessed May 24, 2024.
33. American Heart Association. Transient Ischemic Attack (TIA). Available at https://www.stroke.org/en/about-stroke/types-of-stroke/tia-transient-ischemic-attack. Last accessed May 24, 2024.
34. Centers for Disease Control and Prevention. About Type 2 Diabetes. Available at https://www.cdc.gov/diabetes/about/about-type-2-diabetes.html. Last accessed May 24, 2024.
35. Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2022. Available at https://www.cdc.gov/diabetes/php/data-research/. Last accessed May 24, 2024.
36. Centers for Disease Control and Prevention. Deaths and Mortality. Available at https://www.cdc.gov/nchs/fastats/deaths.htm. Last accessed May 24, 2024.
37. Auluck A. Diabetes Mellitus: An Emerging Risk Factor for Oral Cancer? Available at https://www.cda-adc.ca/jcda/vol-73/issue-6/501.pdf. Last accessed May 24, 2024.
38. MedlinePlus. Metformin. Available at https://medlineplus.gov/druginfo/meds/a696005.html. Last accessed May 24, 2024.
39. Little JW, Rhodus NL. Pharmacologic management of type 2 diabetes: a review for dentistry. Gen Dent. 2007;55(6):564-600.
40. U.S. Food and Drug Administration. FDA Drug Safety Communication: Updated Risk Evaluation and Mitigation Strategy (REMS) to Restrict Access to Rosiglitazone-containing Medicines Including Avandia, Avandamet and Avandaryl. Available at https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-updated-risk-evaluation-and-mitigation-strategy-rems-restrict-access. Last accessed May 24, 2024.
41. U.S. Food and Drug Administration. FDA Drug Safety Communication: FDA Requires Removal of Some Prescribing and Dispensing Restrictions for Rosiglitazone-Containing Diabetes Medicines. Available at https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-requires-removal-some-prescribing-and-dispensing-restrictions. Last accessed May 24, 2024.
42. Sanz M, Ceriello A, Buysschaert M, et al. Scientific evidence on the links between periodontal diseases and diabetes: consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. J Clin Periodontol. 2017;45:138-149.
43. United Nations World Population Ageing 2019: Highlights. Available at https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Highlights.pdf. Last accessed May 24, 2024.
44. Topazian RG, Goldberg MH, Hupp JR. Oral and Maxillofacial Infections. 4th ed. Philadelphia, PA: W.B. Saunders Company; 2002.
46. Preshaw PM, Alba AL, Herrera D, et al. Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012;55(1):21-31.
47. Ryan ME. Diagnostic and therapeutic strategies for the management of the diabetic patient. Compend Contin Educ Dent. 2008;29(1):32-44.
48. Hein C. Scottsdale revisited: the role of dental practitioners in screening for undiagnosed diabetes and the medical co-management of patients with diabetes of those at risk for diabetes. Compend Contin Educ Dent. 2008;29(9):540-553.
49. Centers for Disease Control and Prevention. Arthritis: Disabilities and Limitations. Available at https://www.cdc.gov/arthritis/data_statistics/disabilities-limitations.htm. Last accessed May 24, 2024.
50. Centers for Disease Control and prevention. Osteoarthritis. Available at https://www.cdc.gov/arthritis/types/osteoarthritis.htm. Last accessed May 24, 2024.
51. Centers for Disease Control and Prevention. Rheumatoid Arthritis. Available at https://www.cdc.gov/arthritis/types/rheumatoid-arthritis.html. Last accessed May 24, 2024.
52. Qiao Y, Wang Z, Li Y, Han Y, Zhou Y, Cao X. Rheumatoid arhtritis risk in periodontitis patients: a systematic review and meta-analysis. Jt Bone Spine. 2020;87:556-564.
53. Hussain SB, Botelho J, Machado V, et al. Is there a bidirectional association between rheumatoid arthritis and periodontitis? A systematic review and meta-analysis. Semin Arthritis Rheum. 2020;50:414-422.
54. Ranatunga SKM. Rheumatoid Arthritis. Available at https://emedicine.medscape.com/article/331715-overview. Last accessed May 24, 2024.
55. U.S. National Library of Medicine. Methotrexate Tablet. Available at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8df0780e-0fbd-4ab8-80b0-7a5eaa08ec0a. Last accessed May 24, 2024.
56. Sollecito TP, Abt E, Lockhart PB, et al. The use of prophylactic antibiotics prior to dental procedures in patients with prosthetic joints. JADA. 2015;146(1):11-16.
57. National Institutes of Arthritis and Musculoskeletal and Skin Disease. Bone Health and Osteoporosis. Available at https://www.niams.nih.gov/health-topics/bone-health-and-osteoporosis. Last accessed May 24, 2024.
58. Harvey N, Dennison E, Cooper C. Osteoporosis: impact on health and economics. Nat Rev Rheumatol. 2010;6(2):99-105.
59. American Academy of Orthopaedic Surgeons Position Statement: Osteoporosis/Bone Health in Adults as a National Public Health Priority. Available at https://www.aaos.org/globalassets/about/position-statements/position-statement-1113-osteoporosis-bone-health-in-adults-as-a-national-public-health-priority_revised.v.3.pdf. Last accessed May 24, 2024.
60. National Osteoporosis Foundation. What Women Need to Know. Available at https://www.nof.org/preventing-fractures/general-facts/what-women-need-to-know. Last accessed May 24, 2024.
61. National Osteoporosis Foundation. 54 Million Americans Affected by Osteoporosis and Low Bone Mass. Available at https://www.nof.org/news/54-million-americans-affected-by-osteoporosis-and-low-bone-mass/. Last accessed May 24, 2024.
62. New York State Department of Health. Bone Mineral Density Testing. Available at https://www.health.ny.gov/publications/2045/index.htm. Last accessed May 24, 2024.
63. Bilezikian JP. Efficacy of bisphosphonates in reducing fracture risk in postmenopausal osteoporosis. Am J Med. 2009;122(Suppl 2):14S-21S.
64. American Association of Oral and Maxillofacial Surgeons. Position Paper: Medication-Related Osteonecrosis of the Jaw – 2022 Update. Available at https://www.aaoms.org/docs/govt_affairs/advocacy_white_papers/mronj_position_paper.pdf. Last accessed May 24, 2024.
65. Marx RE, Sawatari Y, Fortin M, Broumand V. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg. 2005;63(11):1567-1575.
66. Blanchaert RH. Bisphosphonate-Related Osteonecrosis of the Jaw. Available at https://emedicine.medscape.com/article/1447355-overview. Last accessed May 20, 2024.
67. Ruggiero SL. Bisphosphonate-related osteonecrosis of the jaw: diagnosis, prevention, and management. Annu Rev Med. 2009;60:85-96.
68. Broderick JM. Osteonecrosis of the Jaw Related to Antiresorptive Therapy. Available at https://www.onclive.com/view/osteonecrosis-of-the-jaw-related-to-antiresorptive-therapy. Last accessed May 24, 2024.
69. Hess LM, Jeter JM, Benham-Hutchins M, Alberts DS. Factors associated with osteonecrosis of the jaw among bisphosphonate users. Am J Med. 2008;121(6):475-483.
70. Centers for Disease Control and Prevention. Leading Causes of Death. Available at https://www.cdc.gov/nchs/fastats/leading-causes-of-death.htm. Last accessed May 24, 2024.
71. National Cancer Institute. Cancer Statistics Explorer Network. Available at https://seer.cancer.gov/statistics-network/. Last accessed May 24, 2024.
72. National Cancer Institute. Cancer Stat Facts: Oral Cavity and Pharynx Cancer. Available at https://seer.cancer.gov/statfacts/html/oralcav.html. Last accessed May 24, 2024.
73. The Oral Cancer Foundation. Cancer Screening Protocols. Available at https://oralcancerfoundation.org/discovery-diagnosis/cancer-screening-protocols. Last accessed May 24, 2024.
74. American Cancer Society. Cancer Facts and Figures, 2024. Available at https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/2024-cancer-facts-figures.html. Last accessed May 24, 2024.
75. Stevenson MM. Head and Neck Cancer Treatment Protocols. Available at https://emedicine.medscape.com/article/2006216-overview. Last accessed May 24, 2024.
76. Baharudin A, Khairuddin A, Nizam A, Samsruddin AR. Evaluation of irradiated salivary gland function in patients with head and neck tumours treated with radiotherapy. J Laryngol Otol. 2009;123(1):108-113.
77. National Cancer Institute. Oral Complications of Cancer Therapies. Available at https://www.cancer.gov/about-cancer/treatment/side-effects/mouth-throat/oral-complications-hp-pdq#_337. Last accessed May 24, 2024.
78. Blanchaert RH. Osteoradionecrosis of the Mandible. Available at https://emedicine.medscape.com/article/851539-overview#a1. Last accessed May 24, 2024.
79. Marx RE, Johnson RP. Studies in the radiobiology of osteoradionecrosis and their clinical significance. Oral Surg Oral Med Oral Pathol. 1987;64(4):379-390.
80. Treister NS. Chemotherapy-Induced Oral Mucositis. Available at https://emedicine.medscape.com/article/1079570-overview. Last accessed May 24, 2024.
81. Dale RA, Harrison JS, Redding SW. Oral complications in cancer chemotherapy, cancer incidence, and mortality in the U.S. Gen Dent. 2004;52(1):64-72.
82. Treister NS. Chemotherapy-Induced Oral Mucositis Treatment and Management. Available at https://emedicine.medscape.com/article/1079570-treatment. Last accessed May 24, 2024.
83. Holm-Pederson P, Walls A, Ship J (eds). Textbook of Geriatric Dentistry. 3rd ed. Copenhagen: Wiley-Blackwell; 2015.
84. Thornburg JE. Gerontological pharmacology. In: Brody TM, Larner J, Minneman KP (eds). Human Pharmacology: Molecular to Clinical. 2nd ed. St. Louis, MO: Mosby; 1994: 855-861.
85. Rho JP, Wong FS. Principles of prescribing medications. In: Yoshikawa TT, Cobbs EL, Brummel-Smith K (eds). Practical Ambulatory Geriatrics. 2nd ed. St. Louis, MO: Mosby; 1998: 19-25.
86. Little JW. Special medical concerns in the dental management of older adults. Gen Dent. 2004;52(2):152-161.
87. Ghezzi EM, Wagner-Lange LA, Schork MA, et al. Longitudinal influence of age, menopause, hormone replacement therapy, and other medication on parotid flow rates in healthy women. J Gerontol A Biol Sci Med Sci. 2000;55(1):M34-M42.
88. Ship JA, Pillemer SR, Baum BJ. Xerostomia and the geriatric patient. J Am Geriatric Soc. 2002;50(3):535-43.
89. Single Care. Prescription Drug Statistics 2024. Available at https://www.singlecare.com/blog/news/prescription-drug-statistics/. Last accessed May 24, 2024.
90. U.S. Food and Drug Administration. Over-the-Counter (OTC) Drugs Branch: The OTC Drug Review. Available at https://www.fda.gov/drugs/enforcement-activities-fda/over-counter-otc-drugs-branch-otc-drug-review. Last accessed May 24, 2024.
91. Cassolato SF, Turnbull RS. Xerostomia: clinical aspects and treatment. Gerodontology. 2003;20(2):64-77.
92. Cleveland Clinic. Dementia. Available at https://my.clevelandclinic.org/health/diseases/9170-dementia. Last accessed May 24, 2024.
93. Anderson HS. Alzheimer Disease. Available at https://emedicine.medscape.com/article/1134817-overview. Last accessed May 24, 2024.
94. Newadkar UR, Khairnar SJ, Dodamani AS, Newadkar RD. Oral health issues and challenges in Parkinson's disease. Int J Nutr Pharmacol Neurol Dis. 2017;7:54.
95. Lyra P, Machado V, Proenca L, et al. Parkinson's disease, periodontitis and patient0related outcomes: a cross-sectional study. Medicina. 2020;56:383.
96. Cen CK, Wu YT, Chang YC. Periodontal inflammatory disease is associated with the risk of Parkinson's disease: a population-based retrospective matched-cohort study. PeerJ. 2017;5:e3647.
97. Friedlander AH, Mahler M, Norman KM, Ettinger RL, Parkinson disease: systemic and orofcaicl manifestations, medical and dental management. J Am Dent Assoc. 2009;140:658-669.
1. National Institute for Health and Care Excellence. Oral Health for Adults in Care Homes. London: National Institute for Health and Care Excellence; 2016. Available at https://www.nice.org.uk/guidance/ng48. Last accessed May 31, 2024.
2. Cohen EEW, LaMonte SJ, Erb NL, et al. American Cancer Society head and neck cancer survivorship care guideline. CA Cancer J Clin. 2016;66(3):203-239. Available at https://acsjournals.onlinelibrary.wiley.com/doi/full/10.3322/caac.21343. Last accessed May 31, 2024.
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