1. Crocq M-A. A history of anxiety: from Hippocrates to DSM. Dialogues Clinl Neurosci. 2015;17(3):319-325.
3. Bateson M, Brilot B, Nettle D. Anxiety: an evolutionary approach. Can J Psychiatry. 2011;56(12):707-715.
4. Marks IM, Nesse RM. Fear and fitness: an evolutionary analysis of anxiety disorders. Ethol Sociobiol. 1994;15(5-6):247-261.
5. Miloyan B, Bulley A, Bandeen-Roche K, Eaton WW, Gonçalves-Bradley DC. Anxiety disorders and all-cause mortality: systematic review and meta-analysis. Soc Psychiatry Psychiatr Epidemiol. 2016;51(11):1467-1475.
6. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (5th ed). Arlington, VA: American Psychiatric Association; 2013.
7. World Health Organization. ICD-10 Classification of Mental and Behavioral Disorders—Diagnostic Criteria for Research, 11th edition. Available at https://icd.who.int/en. Last accessed August 12, 2020.
8. Nesse RM. The smoke detector principle: natural selection and the regulation of defensive responses. Ann N Y Academy Sci. 2001;935:75-85.
9. Nesse RM. Natural selection and the regulation of defenses: a signal detection analysis of the smoke detector principle. Evol Hum Behav. 2005;26(1):88-105.
10. Mogg K, Bradley BP. A cognitive-motivational analysis of anxiety. Behav Res Ther. 1998;36(9):809-848.
11. Moniz E. Prefrontal leucotomy in the treatment of mental disorders 1937. Am J Psychiatry. 1994;151(6 Suppl):236-239.
12. Steele GDF. Persistent anxiety and tachycardia successfully treated by prefrontal leucotomy. Br Med J. 1951;2(4723):84-86.
13. Koenigs M, Huey ED, Calamia M, Raymont V, Tranel D, Grafman J. Distinct regions of prefrontal cortex mediate resistance and vulnerability to depression. J Neurosci. 2008;28(47):12341-12348.
14. Koenigs M, Huey ED, Raymont V, et al. Focal brain damage protects against post-traumatic stress disorder in combat veterans.Nat Neurosci. 2008;11(2):232-237.
15. Koenigs M, Grafman J. Posttraumatic stress disorder: the role of medial prefrontal cortex and amygdala. Neuroscientist. 2009;15(5):540-548.
16. Myers-Schulz B, Koenigs M. Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders. Mol Psychiatry. 2012;17:132-141.
17. Bechara A, Damasio H, Tranel D, Damasio AR. Deciding advantageously before knowing the advantageous strategy. Science. 1997;275(5304):1293-1295.
18. Damasio AR, Tranel D, Damasio H. Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli. Behav Brain Res. 1990;41(2):81-94.
19. Motzkin JC, Philippi CL, Wolf RC, Baskaya MK, Koenigs M. Ventromedial prefrontal cortex lesions alter neural and physiological correlates of anticipation. J Neurosci. 2014;34(31):10430-10437.
20. Philippi CL, Koenigs M. The neuropsychology of self-reflection in psychiatric illness. J Psychiatr Res. 2014;54:55-63.
21. Schneider B, Koenigs M. Human lesion studies of ventromedial prefrontal cortex. Neuropsychologia. 2017;107:84-93.
22. Feinstein JS, Adolphs R, Damasio AR, Tranel D. The human amygdala and the induction and experience of fear. Curr Biol. 2011;21(1):34-38.
23. Bovasso G, Eaton W. Types of panic attacks and their association with psychiatric disorder and physical illness. Compr Psychiatry. 1999;4(6):469-477.
24. Briggs AC, Stretch DD, Brandon S. Subtyping of panic disorder by symptom profile. Br J Psychiatry. 1993;163:201-209.
25. Roberson-Nay R, Kendler KS. Panic disorder and its subtypes: a comprehensive analysis of panic symptom heterogeneity using epidemiological and treatment seeking samples. Psychol Med. 2011;41(11):2411-2421.
26. Deer TM, Calamari JE. Panic symptomatology and anxiety sensitivity in older adults. Journal of Behavior Therapy & Experimental Psychiatry. 1998;29(4):303-316.
27. Keyl PM, Eaton WW. Risk factors for the onset of panic disorder and other panic attacks in a prospective, population-based study. Am J Epidemiol. 1990;131(2):301-311.
28. McCabe L, Cairney J, Veldhuizen S, Herrmann N, Streiner DL. Prevalence and correlates of agoraphobia in older adults. Am J Geriatr Psychiatry. 2006;14(6):515-522.
29. Sheikh JI, Swales PJ, Carlson EB, Lindley SE. Aging and panic disorder: phenomenology, comorbidity, and risk factors. Am J Geriatr Psychiatry. 2004;12(1):102-109.
30. Wittchen HU, Reed V, Kessler RC. The relationship of agoraphobia and panic in a community sample of adolescents and young adults. Arch Gen Psychiatry. 1998;55(11):1017-1024.
31. National Institute on Alcohol Abuse and Alcoholism. National Epidemiological Survey on Alcohol and Related Conditions. Available at https://www.niaaa.nih.gov/research/nesarc-iii. Last accessed February 8, 2022.
32. Depla MFIA, ten Have ML, van Balkom AJLM, de Graaf R. Specific fears and phobias in the general population: results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS). Social Psychiatry & Psychiatric Epidemiology. 2008;43(3):200-208.
33. Magee WJ, Eaton WW, Wittchen HU, McGonagle KA, Kessler RC. Agoraphobia, simple phobia, and social phobia in the National Comorbidity Survey. Archives of General Psychiatry. 1996;53(2):159-168.
34. Stinson FS, Dawson DA, Chou SP, et al. The epidemiology of DSM-IV specific phobia in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychol Med. 2007;37(7):1047-1059.
35. Grenier S, Schuurmans J, Goldfarb M, et al. The epidemiology of specific phobia and subthreshold fear subtypes in a community-based sample of older adults. Depress Anxiety. 2011;28(6):456-463.
36. Miloyan B, Eaton WW. Blood-injection-injury phobia in older adults. Int Psychogeriatriatr. 2016;28(6):897-902.
37. Gretarsdottir E, Woodruff-Borden J, Meeks S, Depp CA. Social anxiety in older adults: phenomenology, prevalence, and measurement. Behav Res Ther. 2004;42(4):459-475.
38. Miloyan B, Bulley A, Pachana NA, Byrne GJ. Social phobia symptoms across the adult lifespan. J Affect Disord. 2014;168(15):86-90.
39. Watkins ER. Constructive and unconstructive repetitive thought. Psychol Bull. 2008;134(2):163-206.
40. Basevitz P, Pushkar D, Chaikelson J, Conway M, Dalton C. Age-related differences in worry and related processes. Int J Aging Hum Dev. 2008;66(4):283-305.
41. Gonçalves DC, Byrne GJ. Who worries most? Worry prevalence and patterns across the lifespan. Int J Geriatr Psychiatry. 2013;28(1):41-49.
42. Gould CE, Edelstein BA. Worry, emotional control, and anxiety control in older and young adults. J Anxiety Disord. 2010;24(7):759-766.
43. Hunt S, Wisocki P, Yanko J. Worry and use of coping strategies among older and younger adults. J Anxiety Disord. 2003;17(5)547-560.
44. Lindesay J, Baillon S, Brugha T, et al. Worry content across the lifespan: an analysis of 16- to 74-year-old participants in the British National Survey of Psychiatric Morbidity 2000. Psychol Med. 2006;36(11):1625-1633.
45. Miloyan B, Pachana NA. Clinical significance of worry and physical symptoms in late-life generalized anxiety disorder. Int J Geriatr Psychiatry. 2015;30(12):1186-1194.
46. Powers CB, Wisocki PA, Whitbourne SK. Age differences and correlates of worrying in young and elderly adults. Gerontologist. 1992;32(1):82-88.
47. Petku, A, Merz C, Wetherell JL. Anxiety disorders in older adulthood. In: Emmelkamp P, Ehring T (eds). The Wiley Handbook of Anxiety Disorders. Malden, MA: Wiley-Blackwell; 2014: 599-611.
48. Wetherell JL. Worry in older adults. In: Davey GC, Wells A (eds). Worry and Its Psychological Disorders: Theory, Assessment and Treatment. Chichester: John Wiley & Sons; 2006: 70-79.
49. Anthony-Bergstone CR, Zarit SH, Gatz M. Symptoms of psychological distress among caregivers of dementia patients. Psychol Aging. 1988;3(3):245-248.
50. Lim WS, Cheah WK, Ali N, et al. Worry about performance: a unique dimension of caregiver burden. Int Psychogeriatr. 2014;26(4):677-696.
51. Razani J, Corona R, Quilici J, et al. The effects of declining functional abilities in dementia patients and increases in psychological distress on caregiver burden over a one-year period. Clin Gerontol. 2014;37(3):235-252.
52. Litwin H, Meir A. Financial worry among older people: who worries and why? J Aging Stud. 2013;27(2):113-120.
53. Diefenbach GJ, Stanley MA, Beck JG. Worry content reported by older adults with and without generalized anxiety disorder. Aging Ment Health. 2001;5(3):269-274.
54. Miloyan B, Byrne GJ, Pachana NA. Threshold and subthreshold generalized anxiety disorder in later life. Am J Geriatr Psychiatry. 2015;23(6):633-641.
55. Wolitzky-Taylor KB, Castriotta N, Lenze EJ, Stanley MA, Craske M.G., Anxiety disorders in older adults: a comprehensive review. Depress Anxiety. 2010;27(2):190-211.
56. Robins LN, Helzer JE, Croughan J, Ratcliff KS. National Institute of Mental Health Diagnostic Interview Schedule: its history, characteristics, and validity. Arch Gen Psychiatry. 1981;38(4):381-389.
57. Kessler RC, Ustün TB. The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI). Int J Methods Psychiatr Res. 2004;13(2):93-121.
58. Di Nardo PA, O'Brien GT, Barlow DH, Waddell MT, Blanchard EB. Reliability of DSM-III anxiety disorder categories using a new structured interview. Arch Gen Psychiatry. 1983;40(10):1070-1074.
59. Williams JB, Gibbon M, First MB, et al. The structured clinical interview for DSM-III-R (SCID). II. Multisite test-retest reliability. Arch Gen Psychiatry. 1992;49(8):630-636.
60. Wing JK, Babor T, Brugha T, et al. SCAN: Schedules for Clinical Assessment in Neuropsychiatry. Arch Gen Psychiatry. 1990;47(6):589-593.
61. Kroenke K, Spitzer RL, Williams JBW, Monahan PO, Löwe B. Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection. Ann Intern Med. 2007;146(5):317-325.
62. Spitzer RL, Kroenke K, Williams JBW, Löwe BA. Brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006;166(10):1092-1097.
63. Plummer F, Manea L, Trepel D, McMillan D. Screening for anxiety disorders with the GAD-7 and GAD-2: a systematic review and diagnostic meta-analysis. Gen Hosp Psychiatry. 2016;39:24-31.
64. Shear MK, Brown TA, Barlow DH. et al. Multicenter collaborative Panic Disorder Severity Scale. Am J Psychiatry. 1997;154(11):1571-1575.
65. Shear MK, Rucci P, Williams J. et al. Reliability and validity of the Panic Disorder Severity Scale: replication and extension.J Psychiatr Res. 2001;35(5):293-296.
66. Connor KM, Davidson JRT, Churchill LE, Sherwood A, Foa E, Weisler RH. Psychometric properties of the Social Phobia Inventory (SPIN): new self-rating scale. Br J Psychiatry. 2000;176:379-386.
67. Connor KM, Kobak KA, Churchill LE, Katzelnick D, Davidson JRT. Mini-SPIN: a brief screening assessment for generalized social anxiety disorder. Depress Anxiety. 2001;14(2):137-140.
68. Seeley-Wait E, Abbott MJ, Rapee RM. Psychometric properties of the Mini-Social Phobia Inventory. J Clin Psychiatry. 2009;11(5):231-236.
69. Norman SB, Cissell SH, Means-Christensen AJ, Stein MB. Development and validation of an Overall Anxiety Sensitivity and Impairment Scale (OASIS). Depress Anxiety. 2006;23(4):245-249.
70. Norman SB, Campbell-Sills L, Hitchcock CA, et al. Psychometrics of a brief measure of anxiety to detect severity and impairment: the Overall Anxiety Severity and Impairment Scale. J Psychiatr Res. 2011;45(2):262-268.
71. Bragdon LB, Diefenbach GJ, Hannan S, Tolin DF. Psychometric properties of the Overall Anxiety Severity and Impairment Scale (OASIS) among psychiatric outpatients. J Affect Disord. 2016;201:112-115.
72. Byrne GJ, Pachana NA, Gonçalves DC, Arnold E, King R, Khoo SK. Psychometric properties and health correlates of the Geriatric Anxiety Inventory in Australian community-residing older women. Aging Ment Health. 2010;14(3):247-254.
73. Pachana NA, Byrne GJ, Siddle H, Koloski N, Harley E, Arnold E. Development and validation of the Geriatric Anxiety Inventory. Int Psychogeriatr. 2007;19(1):103-114.
74. Johnco C, Knight A, Tadic D, Wuthrich VM. Psychometric properties of the Geriatric Anxiety Inventory (GAI) and its short-form (GAI-SF) in a clinical and non-clinical sample of older adults. Int Psychogeriatr. 2015;27(7):1089-1097.
75. Boddice G, Pachana NA, Byrne GJ. The clinical utility of the geriatric anxiety inventory in older adults with cognitive impairment. Nurs Older People. 2008;20(8):36-39.
76. Matheson SF, Byrne GJ, Dissanayaka NN, et al. Validity and reliability of the Geriatric Anxiety Inventory in Parkinson's disease. Australas J Ageing. 2010;31(1):13-16.
77. Byrne GJ, Pachana NA. Development and validation of a short form of the Geriatric Anxiety Inventory: the GAI-SF. Int Psychogeriatr. 2011;23(1):125-131.
78. Segal DL, June A, Payne M, Coolidge FL, Yochim B. Development and initial validation of a self-report assessment tool for anxiety among older adults: the Geriatric Anxiety Scale. J Anxiety Disord. 2010;24709-714.
79. Mueller AE, Segal DL, Gavett B, et al. Geriatric Anxiety Scale: item response theory analysis, differential item functioning, and creation of a ten-item short form (GAS-10). Int Psychogeriatr. 2015;27(7):1099-1111.
80. Guzmán-Vélez E, Feinstein JS, Tranel D. Feelings without memory in Alzheimer disease. Cogn Behav Neurol. 2014;27(3):117-129.
81. McDade-Montez EA, Watson D, O'Hara MW, Denburg NL. The effect of symptom visibility on informant reporting. Psychology and Aging. 2008;23(4):940-946.
82. Streiner DL, Patten SB, Anthony J, Cairney J. Has "lifetime prevalence" reached the end of its life? An examination of the concept. Int J Methods Psychiatr Res. 2009;18(4):221-228.
83. Schacter DL, Gaesser B, Addis DR. Remembering the past and imagining the future in the elderly. Gerontology. 2014;59(2):143-151.
84. Reynolds K, Pietrzak RH, El-Gabalawy R, Mackenzie CS, Sareen J. Prevalence of psychiatric disorders in U.S. older adults: findings from a nationally representative survey. World Psychiatry. 2015;14(1):74-81.
85. Asnaani A, Richey JA, Dimaite R, Hinton DE, Hofmann SG. A Cross-ethnic comparison of lifetime prevalence rates of anxiety disorders. J Nerv Ment Dis. 2010;198(8):551-555.
86. Grant B, Goldstein RB, Chou SP, et al. Sociodemographic and psychopathologic predictors of first incidence of DSM-IV substance use, mood and anxiety disorders: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. Mol Psychiatry. 2009;14(11):1051-1066.
87. Beesdo K, Pine DS, Lieb R, Wittchen H-U. Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder. Arch Gen Psychiatry. 2010;67(1):47-57.
88. Bijl RV, De Graaf R, Ravelli A, Smit F, Vollebergh WAM, Netherlands Mental Health Survey and Incidence Study. Gender and age-specific first incidence of DSM-III-R psychiatric disorders in the general population. Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS). Soc Psychiatry Psychiatr Epidemiol. 2002;37(8):372-379.
89. Eaton WW, Alexandre P, Kessler RC, et al. The population dynamics of mental disorders. In: Eaton WW (ed). Public Mental Health. New York, NY: Oxford University Press; 2014.
90. Grant B, Hasin DS, Blanco C, et al. The epidemiology of social anxiety disorder in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry. 2005;66(11):1351-1361.
91. Grant B, Hasin DS, Stinson FS. Prevalence, correlates, co-morbidity, and comparative disability of DSM-IV generalized anxiety disorder in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychol Med. 2005;35(12) :1747-1759.
92. Almeida OP, Draper B, Pirkis J, et al. Anxiety, depression, and comorbid anxiety and depression: risk factors and outcome over two years. Int Psychogeriatr. 2012;24(10):1622-1632.
93. Beekman AT, de Beurs E, Van Balkom AJ, Deeg DJ, Van Dyck R, van Tilburg W. Anxiety and depression in later life: co-occurrence and communality of risk factors. Am J Psychiatry. 2000;157(1):89-95.
94. Kessler RC, Chiu WT, Jin R, Ruscio AM, Shear K, Walters EE. The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2006;63(4):415-424.
95. Wardenaar KJ, Huang Y, Wojtyniak B, de Jonge P. Comorbidity: the cross-national structure of mental disorders. In: Scott KM, de Jonge P, Stein DJ, Kessler RC (eds). Mental Disorders Around the World: Facts and Figures from the WHO World Mental Health Surveys. Cambridge: Cambridge University Press; 2018: 297-313.
96. Sareen J, Cox BJ, Afifi TO, et al. Anxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adults. Arch Gen Psychiatry. 2005;62(11):1249-1257.
97. Wilgoss TG, Yohannes AM. Anxiety disorders in patients with COPD: a systematic review. Respir Care. 2013;58(5):858-866.
98. Bienvenu O J, Eaton WW. The epidemiology of blood-injection-injury phobia. Psychol Med. 1998;28(5):1129-1136.
99. Witthauer C, Ajdacic-Gross V, Meyer AH, et al. Associations of specific phobia and its subtypes with physical diseases: an adult community study. BMC Psychiatry. 2016;16.
100. Sigström R, Östling S, Karlsson B, Waern M, Gustafson D, Skoog I. A population-based study on phobic fears and DSM-IV specific phobia in 70-year olds. J Anxiety Disord. 2011;25(1):148-153.
101. Sareen J, Cox BJ, Clara I, Asmundson GJG. The relationship between anxiety disorders and physical disorders in the U.S. National Comorbidity Survey. Depress Anxiety. 2005;21(4):193-202.
102. Thibodeau MA, Welch PG, Sareen J, Asmundson GJG. Anxiety disorders are independently associated with suicide ideation and attempts: propensity score matching in two epidemiological samples. Depress Anxiety. 2013;30(10):947-954.
103. Mykletun A, Bjerkeset O, Overland S, Prince M, Dewey M, Stewart R. Levels of anxiety and depression as predictors of mortality: the HUNT study. Br J Psychiatry. 2019;195(2):118-125.
104. Lee WE, Wadsworth MEJ, Hotopf M. The protective role of trait anxiety: a longitudinal cohort study. Psychol Med. 2006;36(3):345-351.
105. Hay JL, McCaul KD, Magnan RE. Does worry about breast cancer predict screening behaviors? A meta-analysis of the prospective evidence. Preventive Medicine. 2006;42(6):401-408.
106. Chapman GB, Coups EJ. Emotions and preventive health behavior: worry, regret, and influenza vaccination. Health Psychology. 2006;25(1):82-90.
107. Dijkstra A, Brosschot J. Worry about health in smoking behaviour change. Behaviour Research and Therapy. 2003;41(9):1081-1092.
108. Byers AL, Yaffe K, Covinsky KE, Friedman MB, Bruce ML. High occurrence of mood and anxiety disorders among older adults: the National Comorbidity Survey-Replication. Arch Gen Psychiatry. 2010;67(5):489-496.
109. Préville M, Boyer R, Grenier S, et al. The epidemiology of psychiatric disorders in Quebec's older adult population. Can J Psychiatry. 2008;53(12):822-832.
110. Mojtabai R, Crum RM. Cigarette smoking and onset of mood and anxiety disorders. Am J Public Health. 2013;103(9):1656-1665.
111. Taylor G, McNeill A, Girling A, Farley A, Lindson-Hawley N, Aveyard P. Change in mental health after smoking cessation: systematic review and meta-analysis. BMJ. 2014;348:g1151.
112. Francis JL, Moitra E, Dyck I, Keller MB. The impact of stressful life events on relapse of generalized anxiety disorder. Depress Anxiety. 2012;29(5):386-391.
113. Keyes KM, Pratt C, Galea S, McLaughlin KA, Koenen KC, Shear MK. The burden of loss: unexpected death of a loved one and psychiatric disorders across the life course in a national study. Am J Psychiatry. 2014;171(8):864-871.
114. Taher D, Mahmud N, Amin R. The effect of stressful life events on generalized anxiety disorder. European Psychiatry. 2015;30(Suppl 1):543.
115. Fenton MC, Keyes KM, Martins SS, Hasin DS. The role of a prescription in anxiety medication use, abuse, and dependence. Am J Psychiatry. 2010;167(10):1247-1253.
116. Martins SS, Fenton MC, Keyes KM, Blanco C, Zhu H, Storr CL. Mood/anxiety disorders and their association with non-medical prescription opioid use and prescription opioid-use disorder: longitudinal evidence from the National Epidemiologic Study on Alcohol and Related Conditions. Psychol Med. 2012;42(6):1261-1272.
117. Melchior M, Prokofyeva E, Younès N, Surkan PJ, Martins SS. Treatment for illegal drug use disorders: the role of comorbid mood and anxiety disorders. BMC Psychiatry. 2014;14:89.
118. Martins SS, Gorelick DA. Conditional substance abuse and dependence by diagnosis of mood or anxiety disorder or schizophrenia in the U.S. population. Drug Alcohol Depend. 2011;119(1-2):28-36.
119. Bulley A, Miloyan B, Brilot B, Gullo MJ, Suddendorf T. An evolutionary perspective on the co-occurrence of social anxiety.J Affect Disord. 2016;196:62-70.
120. Khantzian EJ. The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. Am J Psychiatry. 1985;142(11):1259-1264.
121. Miloyan B, Van Doorn G. Longitudinal association between social anxiety disorder and incident alcohol use disorder: results from two national samples of US adults. Soc Psychiatry Psychiatr Epidemiol. 2019;54(4):469-475.
122. Dissanayaka NN, Sellbach A, Matheson S, O'Sullivan JD. Anxiety disorders in Parkinson's disease: prevalence and risk factors. Movement Disorders. 2010;25(7):838-845.
123. Leentjens AF, Dujardin K, Marsh L, Martinez-Martin P, Richard IH, Starkstein SE. Symptomatology and markers of anxiety disorders in Parkinson's disease: a cross-sectional study. Mov Disord. 2011;26(3):484-492.
124. Pontone GM, Williams JR, Anderson KE, et al. Prevalence of anxiety disorders and anxiety subtypes in patients with Parkinson's disease. Move Disord. 2009;24(9):1333-1338.
125. Stenberg U, Ruland CM, Miaskowski C. Review of the literature on the effects of caring for a patient with cancer. Psychooncology. 2010;19(10):1013-1025.
126. Berger G, Bernhardt T, Weimer E, Peters J, Kratzsch T, Frolich L. Longitudinal study on the relationship between symptomatology of dementia and levels of subjective burden in depression among family caregivers in memory clinic patients. J Geriatr Psychiatry Neurol. 2005;18(3):119-128.
127. Hirschman KB, Xie SX, Feudtner C, Karlawish JHT. How does an Alzheimer's disease patient's role in medical decision-making change over time? J Geriatr Psychiatry Neurol. 2004;17(2):55-60.
128. Razani J, Kakos B, Orita-Barbalace C, et al. Predicting caregiver burden from daily functional abilities of patients with mild dementia. J Am Geriatr Soc. 2007;55(9):1415-1420.
129. Epstein-Lubow G, Davis JD, Miller IW, Tremont G. Persisting burden predicts depressive symptoms in dementia caregivers.J Geriatr Psychiatry Neurol. 2008;21(3):198-203.
130. Pompoli A, Furukawa TA, Imai H, Tajika A, Efthimiou O, Salanti G. Psychological therapies for panic disorder with or without agoraphobia in adults: a network meta-analysis. Cochrane Database Syst Rev. 2016;4(4):CD011004.
131. Pompoli A, Furukawa TA, Efthimiou O, Imai H, Tajika A, Salanti G. Dismantling cognitive-behaviour therapy for panic disorder: a systematic review and component network meta-analysis. Psychol Med. 2018;48(12):1945-1953.
132. Wetherell J, Petkus AJ, Throp SR, et al. Age differences in treatment response to a collaborative care intervention for anxiety disorders. Br J Psychiatry. 2013;203(1):65-72.
133. Mayo-Wilson E, Dias S, Mavranezouli I, et al. Psychological and pharmacological interventions for social anxiety disorder in adults: a systematic review and network meta-analysis. Lancet Psychiatry. 2014;1(5):368-376.
134. Miller KJ, Gonçalves-Bradley DC, Areerob P, Hennessy D, Mesagno C, Grace F. Comparative effectiveness of three exercise types to treat clinical depression in older adults: a systematic review and network meta-analysis of randomised controlled trials. Ageing Res Rev. 2020;58:100999.
135. Cuijpers P, Sijbrandij M, Koole S, Huibers M, Berking M, Andersson G. Psychological treatment of generalized anxiety disorder: a meta-analysis. Clin Psychol Rev. 2014;34(2):130-140.
136. Baldwin D, Woods R, Lawson R, Taylor D. Efficacy of drug treatments for generalized anxiety disorder: systematic review and meta-analysis. BMJ. 2011;342:d1199.
137. Mavranezouli I, Meader N, Cape J, Kendall T. The cost effectiveness of pharmacological treatments for generalized anxiety disorder. PharmacoEconomics. 2013;31(4):317-333.
138. Hall J, Kellett S, Berrios R, Bains MK, Scott S. Efficacy of cognitive behavioral therapy for generalized anxiety disorder in older adults: systematic review, meta-analysis, and meta-regression. Am J Geriatr Psychiatry. 2016;24(11):1063-1073.
139. Choy Y, Fyer AJ, Lipsitz JD. Treatment of specific phobia in adults. Clin Psychol Rev. 2007;27(3):266-286.
140. Wolitzky-Taylor KB, Horowitz JD, Powers MB, Telch MJ. Psychological approaches in the treatment of specific phobias: a meta-analysis. Clin Psychol Rev. 2008;28(6):1021-1037.
141. Rothbaum BO, Hodges LF, Kooper R, Opdyke D, Williford JS, North M. Effectiveness of computer-generated (virtual reality) graded exposure in the treatment of acrophobia. Am J Psychiatry. 1995;152(4):626-628.
143. 143. Öst LG, Brandberg M, Alm T. One versus five sessions of exposure in the treatment of flying phobia. Behav Res Ther. 1997;35(11):987-996.
144. 144. Öst LG. One-session treatments for a case of multiple simple phobias. Scandinavian Journal of Behaviour Therapy. 1987;16(4):175-184.
145. 145. Öst LG, Hellström K, Kåver A. One versus five sessions of exposure in the treatment of injection phobia. Behav Ther. 1992;23(2):263-281.
146. Abramowitz JS. The practice of exposure therapy: relevance of cognitive-behavioral theory and extinction theory. Behav Ther. 2013;44(4):548-558.
147. de Quervain DJF, Bentz D, Michael T, Bolt OC, et al. Glucocorticoids enhance extinction-based psychotherapy. Proc Natl Acad Sci USA. 2011;108(16):6621-6625.
148. Soravia LM, Heinrichs M, Winzeler L, et al. Glucocorticoids enhance in vivo exposure-based therapy of spider phobia. Depress Anxiety. 2014;31(5):429-435.
149. Davis M. Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy. Eur J Neurosci. 2002;16(3):395-398.
150. Ressler KJ, Rothbaum BO, Tannenbaum L, et al. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry. 2004;61(11):1136-1144.
151. Mataix-Cols D, Fernández de la Cruz L, Monzani B,et al. D-cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders: a systematic review and meta-analysis of individual participant data. JAMA Psychiatry. 2017;74(5):501-510.
152. Opatowski L, Mandel J, Varon E, Boëlle P-Y, Temime L, Guillemot D. Antibiotic dose impact on resistance selection in the community: a mathematical model of beta-lactams of streptococcus pneumoniae dynamics. Antimicrob Agents Chemother. 2010;54(6):2330-2337.
153. Roberts JA, Druger P, Paterson DL, Lipman J. Antibiotic resistance: what's dosing got to do with it? Critical Care Medicine. 2008;36:2433-2440.
154. Bouton ME. Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Biol Psychiatry. 2002;52(10):976-986.
155. Lipsitz JD, Mannuzza S, Klein DF, Ross DC, Fyer AJ. Specific phobia 10–16 years after treatment. Depression and Anxiety. 1999;10:105-111.
156. Rodriguez BI, Craske MG, Mineka S, Hladek D. Context-specificity of relapse: effects of therapist and environmental context on return of fear. Behav Res Ther. 1999;37(9):845-862.
157. Vervliet B, Craske MG, Hermans D. Fear extinction and relapse: state of the art. Ann Rev Clin Psychol. 2013;9:215-248.
158. Bandarian-Balooch, S, Neumann DL, Boschen MJ. Exposure treatment in multiple contexts attenuates return of fear via renewal in high spider fearful individuals. J Behav Ther Exp Psychiatry. 2015;47:138-144.
159. Dunsmoor JE, Ahs F, Zielinski DJ, LaBar KS. Extinction in multiple virtual reality contexts diminishes fear reinstatement in humans. Neurobiol Learn Mem. 2014;113:157-164.
160. Shiban Y, Pauli P, Mühlberger A. Effect of multiple context exposure on renewal in spider phobia. Behav Res Ther. 2013;51(2):68-74.
1. National Collaborating Centre for Mental Health. Social Anxiety Disorder: Recognition, Assessment and Treatment. London: National Institute for Health and Care Excellence; 2013. Available at https://www.nice.org.uk/guidance/cg159/resources/social-anxiety-disorder-recognition-assessment-and-treatment-pdf-35109639699397. Last accessed February 17, 2022.
2. National Collaborating Centre for Mental Health, National Collaborating Centre for Primary Care. Generalised Anxiety Disorder and Panic Disorder in Adults: Management. London: National Institute for Health and Clinical Excellence; 2019. Available at https://www.nice.org.uk/guidance/cg113. Last accessed February 17, 2022.
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